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Titolo:
Anti-adhesive strategies in the prevention of infectious disease at mucosal surfaces
Autore:
Kelly, CG; Younson, JS;
Indirizzi:
Univ London Kings Coll, Guys Kings & St Thomas Sch Med & Dent, Dept Oral Med & Pathol, Immunol Unit, London WC2R 2LS, England Univ London Kings CollLondon England WC2R 2LS London WC2R 2LS, England
Titolo Testata:
EXPERT OPINION ON INVESTIGATIONAL DRUGS
fascicolo: 8, volume: 9, anno: 2000,
pagine: 1711 - 1721
SICI:
1354-3784(200008)9:8<1711:ASITPO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCAL PASSIVE-IMMUNIZATION; HELICOBACTER-PYLORI INFECTION; FIBRONECTIN-BINDING PROTEIN; ESCHERICHIA-COLI; MONOCLONAL-ANTIBODIES; CANDIDA-ALBICANS; PSEUDOMONAS-AERUGINOSA; RHINOVIRUS INFECTION; STREPTOCOCCUS-MUTANS; BORDETELLA-PERTUSSIS;
Keywords:
adhesin; adhesion epitope; Candida albicans; clinical trial; microbial adhesion; monoclonal antibody; oligosaccharide; receptor analogue; Streptococcus mutans; Streptococcus pneumoniae;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Kelly, CG Guys Hosp, Dept Oral Med & Pathol, Floor 28,Guys Tower, London SE1 9RT, England Guys Hosp Floor 28,Guys Tower London England SE1 9RT T, England
Citazione:
C.G. Kelly e J.S. Younson, "Anti-adhesive strategies in the prevention of infectious disease at mucosal surfaces", EXPERT OP I, 9(8), 2000, pp. 1711-1721

Abstract

Binding of microbial cell surface adhesins to host receptor molecules is acritical early step in microbial infection and pathogenesis. Anti-adhesivestrategies aimed at blocking this interaction offer an attractive means ofpreventing infection at an early stage. The strategy should reduce the likelihood of resistant strains of microorganisms emerging, since those that do not bind will not be subjected to sustained selective pressure, as may occur with antibiotic therapy. Three classes of adhesion-blocking agent have been investigated, namely anti-adhesin antibodies, adhesin analogues and receptor analogues. The effectiveness of a number of these adhesion-blocking compounds has been demonstrated in human and animal models of infection. Direct application to the tooth surface of anti-adhesin monoclonal antibody, or a synthetic peptide adhesion epitope, prevented infection with the oral pathogen, Streptococcus mutans in humans. Intranasal administration of a soluble receptor analogue significantly reduced virus production and symptomsfollowing experimental infection with rhinovirus. Similarly, all three types of anti-adhesion agent protected against a variety of infections at other mucosal surfaces in animal models. A common finding from these studies isthe long duration of protection, which cannot be due to persistence of theanti-adhesion agent, but may be the result of competitive exclusion by members of the normal flora at specific mucosal surfaces. Development of thesenovel antimicrobial agents is particularly timely in view of the increasing concern over the spread of antibiotic resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 02:46:24