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Titolo:
Interindividual variability of the modulatory effects of repetitive transcranial magnetic stimulation on cortical excitability
Autore:
Maeda, F; Keenan, JP; Tormos, JM; Topka, H; Pascual-Leone, A;
Indirizzi:
Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Neurol,Lab Magnet Brain Stimulat, Boston, MA 02215 USA Harvard Univ Boston MA USA 02215 net Brain Stimulat, Boston, MA 02215 USA Keio Univ, Sch Med, Dept Neuropsychiat, Tokyo, Japan Keio Univ Tokyo Japan o Univ, Sch Med, Dept Neuropsychiat, Tokyo, Japan Miguel Hernandez Univ, Inst Bioengn, Alicante, Spain Miguel Hernandez Univ Alicante Spain niv, Inst Bioengn, Alicante, Spain Univ Tubingen, Dept Neurol, D-7400 Tubingen, Germany Univ Tubingen Tubingen Germany D-7400 t Neurol, D-7400 Tubingen, Germany
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 4, volume: 133, anno: 2000,
pagine: 425 - 430
SICI:
0014-4819(200008)133:4<425:IVOTME>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MOTOR CORTEX; COIL ORIENTATION; DEPRESSION; RESPONSES; ACCURACY; SAFETY; BRAIN; TMS;
Keywords:
repetitive transcranial magnetic stimulation (rTMS); train; frequency tuning curve; cortical excitability; neurophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Maeda, F Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Neurol,Lab Magnet Brain Stimulat, 330 Brookline Ave KS452, Boston, MA 02215 USA Harvard Univ 330 Brookline Ave KS452 Boston MA USA 02215 2215 USA
Citazione:
F. Maeda et al., "Interindividual variability of the modulatory effects of repetitive transcranial magnetic stimulation on cortical excitability", EXP BRAIN R, 133(4), 2000, pp. 425-430

Abstract

Repetitive transcranial magnetic stimulation (rTMS) appears to have effects on cortical excitability that extend beyond the train of rTMS itself. These effects may be inhibitory or facilitatory and appear to depend on the frequency, intensity, duration and intertrain interval of the rTMS. Many studies assume facilitatory effects of high-frequency rTMS and inhibitory effects of low-frequency rTMS. Nevertheless, the interindividual variability of this modulation of cortical excitability by rTMS has not been systematically investigated. In this study, we applied 240 pulses of rTMS at 90% of the subjects' motor threshold to their motor cortex at different frequencies (1, 10, 15 and 20 Hz) and examined the effects on motor evoked potentials (frequency tuning curve). Although the averaged group data showed a frequency-dependent increase in cortical excitability, each subject had a different pattern of frequency tuning curve, i.e. a different modulatory effect on cortical excitability at different rTMS frequencies. The interindividual variability of these modulatory effects was still high, though less so, when thenumber of rTMS pulses was increased to 1600. These findings illustrate thedegree of variability of the rTMS effects in the human brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 05:58:09