Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Muscle metabolic status in patients with severe COPD with and without long-term prednisolone
Autore:
Pouw, EM; Koerts-de lang, E; Gosker, HR; Freling, G; van der Vusse, G; Wouters, EFM; Schols, AMWJ;
Indirizzi:
Maastricht Univ, Dept Pulmonol, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands ulmonol, Maastricht, Netherlands Maastricht Univ, Dept Physiol, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands Physiol, Maastricht, Netherlands Maastricht Univ, Dept Pathol, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands Pathol, Maastricht, Netherlands Asthmactr Hornerheide, Horn, Netherlands Asthmactr Hornerheide Horn Netherlands r Hornerheide, Horn, Netherlands
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 2, volume: 16, anno: 2000,
pagine: 247 - 252
SICI:
0903-1936(200008)16:2<247:MMSIPW>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; STEROID-INDUCED MYOPATHY; GLYCOGEN-METABOLISM; SKELETAL-MUSCLE; ENZYME-ACTIVITY; WEAKNESS; EXERCISE;
Keywords:
adenine nucleotide; biochemistry; chronic obstructive pulmonary disease; corticosteroids; myopathy; skeletal muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Schols, AMWJ Univ Hosp Maastricht, Dept Pulmonol, POB 5800, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht POB 5800 Maastricht Netherlands NL-6202 AZ
Citazione:
E.M. Pouw et al., "Muscle metabolic status in patients with severe COPD with and without long-term prednisolone", EUR RESP J, 16(2), 2000, pp. 247-252

Abstract

Both abnormalities in high energy phosphate metabolism and a decreased oxidative enzyme capacity have been reported in skeletal muscle of stable chronic obstructive pulmonary disease (COPD) patients, The first aim of this study was to investigate whether these findings are present in anterior tibialis muscle and whether or not they are associated. Abnormalities in mitochondrial structure and function as well as signs of myopathy have been found during corticosteroid treatment. The second aim of this study therefore, was to investigate whether in COPD patients prolonged use of low dose prednisolone has effects on muscle energy metabolism and qualitative morphology. In a cross-sectional study 15 COPD patients (forced expiratory volume in one second (FEV1) 33+/-9 (mean+/-SD) % predicted) who were steroid-naive (CORT-) were compared with 10 healthy control subjects (HC) and with 14 COPD patients (FEV1 30+/-11 % pred), who had been using oral prednisolone for at least 1 yr (CORT+),It was found that adenosine triphosphate (ATP)/adenosine diphosphate was lower in CORT- compared to HC (5.7 versus 6.2, p=0.03), Inosine monophosphate was detected in 13 of 15 CORT- compared to 3 of 10 HC (p=0.004). However,although indications were found for an imbalance in production and utilization of ATP, comparing CORT- and HC, no differences in oxidative (citrate synthase and 3-hydroxy-acyl-coenzyme me A dehydrogenase) and glycolytic (hexokinase, lactate dehydrogenase and phosphofructokinase) enzyme capacities were found. When, comparing steroid-treated and steroid-naive patient subgroups, no differences in the above mentioned parameters of muscle energy metabolism andof muscle qualitative morphology were found.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 15:58:51