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Titolo:
Interaction between NSAIDs and steroid in rat stomach - Safety of nimesulide as a preferential COX-2 inhibitor in the stomach
Autore:
Kataoka, H; Horie, Y; Koyama, R; Nakatsugi, S; Furukawa, M;
Indirizzi:
Sawai Pharmaceut Co Ltd, Osaka Res Lab, Asahi Ku, Osaka 5350004, Japan Sawai Pharmaceut Co Ltd Osaka Japan 5350004 ahi Ku, Osaka 5350004, Japan
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 7, volume: 45, anno: 2000,
pagine: 1366 - 1375
SICI:
0163-2116(200007)45:7<1366:IBNASI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PROSTAGLANDIN ENDOPEROXIDE SYNTHASE; GASTRIC-LESIONS; DIFFERENTIAL INHIBITION; SELECTIVE-INHIBITION; EPITHELIAL RENEWAL; MESSENGER-RNA; INDOMETHACIN; DAMAGE; PROSTACYCLIN;
Keywords:
NSAIDs; nimesulide; steroid; cyclooxgenase; drug interaction; gastric lesion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Furukawa, M Sawai Pharmaceut Co Ltd, Osaka Res Lab, Asahi Ku, 1-8-14 Ikue,Osaka 5350004, Japan Sawai Pharmaceut Co Ltd 1-8-14 Ikue Osaka Japan 5350004 Japan
Citazione:
H. Kataoka et al., "Interaction between NSAIDs and steroid in rat stomach - Safety of nimesulide as a preferential COX-2 inhibitor in the stomach", DIG DIS SCI, 45(7), 2000, pp. 1366-1375

Abstract

The relative risk of development of peptic ulcer with the use of nonsteroidal antiinflammatory drugs (NSAIDs) has been reported to increase when these drugs are administered in combination with steroids. We investigated the ulcerogenic potential of a combination of NSAIDs and steroids in rats and the underlying pathogenic mechanisms. Indomethacin alone produced gastric lesions, and the severity of the lesions markedly increased with concomitant administration of prednisolone. However, nimesulide, even in excessive doses, did not produce any gastric lesions, regardless of concomitant administration with prednisolone, Furthermore, we showed that the ulcerogenic potential of indomethacin administered in combination with prednisolone may be related to the induction of physiological changes, such as endogenous prostaglandin deficiency, an increase in neutrophil activation, and gastric hypermotility, by indomethacin and alteration of normal epithelial renewal by thesteroid. These results suggest that the ulcerogenic potential of preferential a COX-1 inhibitor increases following concomitant administration with asteroid, whereas, nimesulide, a preferential COX-2 inhibitor, is nonulcerogenic, even when administered concomitantly with a steroid, and is therefore a clinically useful antiinflammatory agent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:54:07