Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of Helicobacter pylori eradication on 24-hour gastric pH and duodenal gastric metaplasia
Autore:
Savarino, V; Mela, GS; Zentilin, P; Mele, MR; Bisso, G; Pivari, M; Mansi, C; Tessieri, L; Lapertosa, G; Ceppa, P; Vigneri, S;
Indirizzi:
Univ Genoa, Cattedra Gastroenterol, DIMI, Dipartimento Med Interna & Specialita Med, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 na & Specialita Med, I-16132 Genoa, Italy Univ Genoa, Dipartimento Discipline Chirurg Morfol & Metodol, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 rg Morfol & Metodol, I-16132 Genoa, Italy Univ Palermo, Ist Med Interna & Geriatria, Palermo, Italy Univ Palermo Palermo Italy Ist Med Interna & Geriatria, Palermo, Italy
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 7, volume: 45, anno: 2000,
pagine: 1315 - 1321
SICI:
0163-2116(200007)45:7<1315:EOHPEO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ULCER PATIENTS; ACID-SECRETION; CAMPYLOBACTER-PYLORI; INTRAGASTRIC PH; BICARBONATE SECRETION; INFLAMMATION; MUCOSA; INFECTION; OUTPUT; PATHOGENESIS;
Keywords:
duodenal gastric metaplasia; duodenal ulcer; gastric pH; H. pylori;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Savarino, V Univ Genoa, Cattedra Gastroenterol, DIMI, Dipartimento Med Interna & Specialita Med, Viale Benedetto 15,6, I-16132 Genoa, Italy Univ Genoa Viale Benedetto 15,6 Genoa Italy I-16132 oa, Italy
Citazione:
V. Savarino et al., "Effect of Helicobacter pylori eradication on 24-hour gastric pH and duodenal gastric metaplasia", DIG DIS SCI, 45(7), 2000, pp. 1315-1321

Abstract

Published data on the regression of the extent of duodenal gastric metaplasia (DCM) after the eradication of Helicobacter pylori infection and the normalization of the organism-induced alterations in gastric physiology are scanty and controversial, Therefore, we decided to assess the circadian pattern of gastric acidity and the degree of DGM before and one year after H. pylori eradication in a group of duodenal ulcer patients. Fifteen consecutive H. pylori-positive patients with endoscopically proven duodenal ulcer were recruited fur this study. The diagnosis of H. pylori infection was based on CLO-test and histology, and DGM was assessed on four bulb biopsies takenbefore and one year after H. pylori eradication. At the same time, gastricpH was measured by 24-hr continuous intraluminal recording. H. pylori eradication was ascertained by means of concomitant negative CLO-test and histology performed both four weeks after the end of the eradicating treatment and at the one-year endoscopic control. After successful cure, all patients discontinued any antiulcer medication. The mean 24-hr gastric pH was 1.7 +/- 0.4 before and 1.6 +/- 0.4 after one year of H. pylori eradication (P = 0.75). DGM improved in three cases, worsened in four cases, and was unchanged in eight cases at the one-year control (P = 0.87). No correlation was found between 24-hr gastric pH and DGM (P = NS) both at baseline and one year after eradication, Our results show that neither circadian gastric acidity nor DGM change significantly one year after H. pylori eradication in duodenal ulcer patients. Thus, the disappearance of H. pylori infection does not determine any increase in gastric pH and any reversal of gastric-type epithelium in the duodenum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:06:49