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Titolo:
Notch signaling regulates the pattern of auditory hair cell differentiation in mammals
Autore:
Zine, A; Van de Water, TR; de Ribaupierre, F;
Indirizzi:
Univ Lausanne, Inst Physiol, CH-1005 Lausanne, Switzerland Univ Lausanne Lausanne Switzerland CH-1005 CH-1005 Lausanne, Switzerland Albert Einstein Coll Med, Dept Otolaryngol & Neurosci, Bronx, NY 10461 USAAlbert Einstein Coll Med Bronx NY USA 10461 Neurosci, Bronx, NY 10461 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 15, volume: 127, anno: 2000,
pagine: 3373 - 3383
SICI:
0950-1991(200008)127:15<3373:NSRTPO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
INNER-EAR; ANTISENSE OLIGONUCLEOTIDE; FATE; EXPRESSION; DROSOPHILA; DELTA; GENE; LIGAND; NEUROGENESIS; RECEPTOR;
Keywords:
Notch1; Jagged1; Jagged2; organ of Corti; inner ear; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: de Ribaupierre, F Univ Lausanne, Inst Physiol, CH-1005 Lausanne, Switzerland Univ Lausanne Lausanne Switzerland CH-1005 Switzerland
Citazione:
A. Zine et al., "Notch signaling regulates the pattern of auditory hair cell differentiation in mammals", DEVELOPMENT, 127(15), 2000, pp. 3373-3383

Abstract

The development of the mammalian cochlea is an example of patterning in the peripheral nervous system. Sensory hair cells and supporting cells in thecochlea differentiate via regional and cell fate specification. The Notch signaling components shows both distinct and overlapping expression patterns of Notch1 receptor and its ligands Jagged1 (Jag1) and Jagged2 (Jag2) in the developing auditory epithelium of the rat. On embryonic day 16 (E16), many precursor cells within the Kolliker's organ immunostained for the presence of both Notch1 and Jag1, while the area of hair cell precursors did not express either Notch1 and Jag1. During initial events of hair cell differentiation between E18 and birth, Notch1 and Jag1 expression predominated in supporting cells and Jag2 in nascent hair cells. Early after birth, Jag2 expression decreased in hair cells while the pattern of Notch1 expression now included both supporting cells and hair cells. We show that the normal pattern of hair cell differentiation is disrupted by alteration of Notch signaling. A decrease of either Notch1 or Jag1 expression by antisense oligonucleotides in cultures of the developing sensory epithelium resulted in an increase in the number of hair cells. Our data suggest that the Notch1 signaling pathway is involved in a complex interplay between the consequences of different ligand-Notch1 combinations during cochlear morphogenesis and the phases of hair cell differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 06:48:00