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Titolo:
Mechanical ventilation with high positive end-expiratory pressure and small driving pressure amplitude is as effective as high-frequency oscillatory ventilation to preserve the function of exogenous surfactant in lung-lavaged rats
Autore:
de Anda, GFV; Gommers, D; Verbrugge, SJC; De Jaegere, A; Lachmann, B;
Indirizzi:
Erasmus Univ, Dept Anesthesiol, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Inst Mexicano Seguro Social, Ctr Med Nacl Siglo 21, Hosp Especialidades Drbernardo Sepulveda G, Unidad Ciudados Intens, Mexico City 06725, DF, MexicoInst Mexicano Seguro Social Mexico City DF Mexico 06725 06725, DF, Mexico
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 8, volume: 28, anno: 2000,
pagine: 2921 - 2925
SICI:
0090-3493(200008)28:8<2921:MVWHPE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; THERAPY; RABBITS; INJURY; MODEL;
Keywords:
respiratory distress syndrome; pulmonary surfactant; pressure controlled ventilation; high-frequency oscillatory ventilation; recruitment procedure; respiratory mechanics; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Lachmann, B Erasmus Univ, Dept Anesthesiol, Room Ee 2393,POB 1738, NL-3000DR Rotterdam, Netherlands Erasmus Univ Room Ee 2393,POB 1738 Rotterdam Netherlands NL-3000 DR
Citazione:
G.F.V. de Anda et al., "Mechanical ventilation with high positive end-expiratory pressure and small driving pressure amplitude is as effective as high-frequency oscillatory ventilation to preserve the function of exogenous surfactant in lung-lavaged rats", CRIT CARE M, 28(8), 2000, pp. 2921-2925

Abstract

Objective: To demonstrate that under well-defined conditions, pressure-controlled ventilators (PCV) allow settings that are as good as high-frequencyoscillatory ventilators (HFOV) at preserving the function of exogenous surfactant in lung-lavaged rats. Design: Experimental, comparative study. Setting: Research laboratory of a large university. Subjects: Sixteen adult male Sprague-Dawley rats (280-310 g). Interventions: Lung injury was induced by repeated lavage. After last lavage, all animals received exogenous surfactant and were then randomly assigned to two groups (n = 8 per group). The first group received PCV with smallpressure amplitudes and high positive end-expiratory pressure. The second group received HFOV. In both groups, an opening maneuver was performed by increasing airway pressure to improve PaO2/FIO2 to greater than or equal to 500 torr. Measurements and Main Results: Blood gases were measured every 30 mins for3 hrs. Airway pressures were measured with a tip catheter pressure transducer. At the end of the study period, a pressure-volume curve was recorded and a broncho-alveolar lavage was performed to determine protein content andsurfactant composition. The results showed that arterial oxygenation in both groups could be kept >500 torr during the 3-hr study period by using a mean airway pressure of 13 +/- 3 cm H2O in PCV and 13 +/- 2 cm H2O in HFOV. Further, there were no differences in the Gruenwald index, protein influx, or ratio of small to large aggregates between the study groups. Conclusion: PCV with sufficient level of positive end-expiratory pressure and small driving pressure amplitudes is as effective as HFOV to maintain optimal gas exchange, to improve lung mechanics, and to prevent protein influx and conversion of large into small aggregates after exogenous surfactanttherapy in lung-lavaged rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:43:36