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Titolo:
Antiviral therapy to prevent and treat hepatitis B virus infection in hepatic allografts
Autore:
Perrillo, RP;
Indirizzi:
Alton Ochsner Med Fdn & Ochsner Clin, Dept Gastroenterol & Hepatol, New Orleans, LA 70121 USA Alton Ochsner Med Fdn & Ochsner Clin New Orleans LA USA 70121 A 70121 USA
Titolo Testata:
CLINICAL TRANSPLANTATION
, volume: 14, anno: 2000, supplemento:, 2
pagine: 25 - 28
SICI:
0902-0063(200008)14:<25:ATTPAT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORTHOTOPIC LIVER-TRANSPLANTATION; PASSIVE-IMMUNIZATION; IMMUNE GLOBULIN; PROPHYLAXIS; LAMIVUDINE; RECURRENCE; IMMUNOGLOBULIN; REPLICATION; RESISTANCE; RECIPIENTS;
Keywords:
antibody; famciclovir; ganciclovir; HBIg; hepatitis B; lamivudine; liver; nucleoside analogues; resistance; transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Perrillo, RP Alton Ochsner Med Fdn & Ochsner Clin, Dept Gastroenterol & Hepatol, 1514 Jefferson Highway,Riin 9088, New Orleans, LA 70121 USA Alton Ochsner Med Fdn & Ochsner Clin 1514 Jefferson Highway,Riin 9088 New Orleans LA USA 70121
Citazione:
R.P. Perrillo, "Antiviral therapy to prevent and treat hepatitis B virus infection in hepatic allografts", CLIN TRANSP, 14, 2000, pp. 25-28

Abstract

Hepatitis B infection of a liver allograft can have serious consequences including a negative influence on the probability of survival. Therefore, there is a need for very effective antiviral therapy for transplant recipients, In this article the early experience with nucleoside analogue antiviral agents, both to prevent and to treat hepatitis B in liver allografts, is reviewed. There are several important characteristics of these agents that are already apparent. Ganciclovir and famciclovir have limited efficacy in treating infections when they are used alone. These compounds might be beneficial if used after resistance develops to other drugs or when used in combination with other agents. Lamivudine is effective for about two-thirds of patients in preventing and treating hepatitis B infection in allografts. Hepatitis B immune globulin (HBIg) is known to increase the efficacy of lamivudine in preventing infection. A large study to further characterize this combination therapy is being organized. Resistance to famciclovir and lamivudine can occur if they are used alone for a long time. In order to lower theincidence of drug resistance, it may be necessary to utilize combinations of nucleoside analogues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:39:07