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Titolo:
Mutagenic nitrated benzo[a]pyrene derivatives in the reaction product of benzo[a]pyrene in NO2-air in the presence of O-3 or under photoirradiation
Autore:
Ishii, S; Hisamatsu, Y; Inazu, K; Kobayashi, T; Aika, K;
Indirizzi:
Natl Inst Publ Hlth, Dept Community Environm Sci, Minato Ku, Tokyo 1088636, Japan Natl Inst Publ Hlth Tokyo Japan 1088636 Minato Ku, Tokyo 1088636, Japan Tokyo Inst Technol, Interdisciplinary Grad Sch Sci & Engn, Dept Environm Chem & Engn, Midori Ku, Yokohama, Kanagawa 2268502, Japan Tokyo Inst Technol Yokohama Kanagawa Japan 2268502 anagawa 2268502, Japan
Titolo Testata:
CHEMOSPHERE
fascicolo: 11, volume: 41, anno: 2000,
pagine: 1809 - 1819
SICI:
0045-6535(200012)41:11<1809:MNBDIT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYCLIC AROMATIC-HYDROCARBONS; SOLID HETEROGENEOUS PHOTOREACTION; K-REGION DERIVATIVES; CHEMICAL CARCINOGENESIS; PARTICULATE MATTER; NITRO-DERIVATIVES; DIESEL EXHAUST; AIRBORNE; 1-NITROPYRENE; NITROARENES;
Keywords:
mutagen; nitrobenzo[a]pyrene; Salmonella typhimurium strains; airborne particulate matter; degradation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hisamatsu, Y Natl Inst Publ Hlth, Dept Community Environm Sci, Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088636, Japan Natl Inst Publ Hlth 4-6-1 Shirokanedai Tokyo Japan 1088636 n
Citazione:
S. Ishii et al., "Mutagenic nitrated benzo[a]pyrene derivatives in the reaction product of benzo[a]pyrene in NO2-air in the presence of O-3 or under photoirradiation", CHEMOSPHERE, 41(11), 2000, pp. 1809-1819

Abstract

In order to clarify the contribution of nitrated products to the direct-mutagenic activity of products of the reactions of benzo[a]pyrene in NO2-air under various conditions, heterogeneous reactions of BaP deposited on filter in the air containing 10 ppm of NO2 have been conducted in dark or under photoirradiation. The reaction products have been analyzed by gas chromatography and mutagenicity of the products fractionated by preparative HPLC wasassayed for Salmonella typhimurium strains TA98 and YG1024 in the absence of S9 mix. 3,6-dinitrobenzo[a]pyrene and 1,3-dinitrobenzo[a]pyrene, which are strong direct-acting mutagens, largely contributed to the total direct-acting mutagenicity of the dark reaction products in NO2-air. On the other hand, both the dark reaction in the presence of O-3 and the photoreaction inNO2-air resulted in the formation of much smaller amounts of nitrobenzo[a]pyrenes than that observed in the dark reaction in the absence of O-3. These results show that the contribution of other direct-acting mu; tagens to the total direct-acting mutagenicity of the products in these reactions should be considered. Benzo[a]pyrene lactones were identified in a highly mutagenic fraction of the products of the dark reaction in the presence of O-3 and photoreaction and a nitrobenzo[a]pyrene lactone was also identified in ahighly mutagenic fraction of the dark reaction products in the presence ofO-3. Nitrated oxygenated benzo[a]pyrene derivatives such as nitrobenzo[a]pyrene lactone were considered to largely contribute to direct-acting mutagenicity of the products of the dark reaction in the presence of O-3 and photoreaction. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 18:31:04