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Titolo:
Angiogenesis induced by the implantation of self-bone marrow cells: A new material for therapeutic angiogenesis
Autore:
Hamano, K; Li, TS; Kobayashi, T; Kobayashi, S; Matsuzaki, M; Esato, K;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Surg 1, Yamaguchi 7558505, Japan Yamaguchi Univ Yamaguchi Japan 7558505 Surg 1, Yamaguchi 7558505, Japan Yamaguchi Univ, Sch Med, Dept Physiol 1, Yamaguchi 7558505, Japan Yamaguchi Univ Yamaguchi Japan 7558505 ysiol 1, Yamaguchi 7558505, Japan Yamaguchi Univ, Sch Med, Dept Internal Med 2, Yamaguchi 7558505, Japan Yamaguchi Univ Yamaguchi Japan 7558505 l Med 2, Yamaguchi 7558505, Japan
Titolo Testata:
CELL TRANSPLANTATION
fascicolo: 3, volume: 9, anno: 2000,
pagine: 439 - 443
SICI:
0963-6897(200005/06)9:3<439:AIBTIO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; NEOVASCULARIZATION; HYPOXIA;
Keywords:
angiogenesis; bone marrow cells; ischemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Hamano, K Yamaguchi Univ, Sch Med, Dept Surg 1, 1-1-1 Minamikogushi, Yamaguchi 7558505, Japan Yamaguchi Univ 1-1-1 Minamikogushi Yamaguchi Japan 7558505 apan
Citazione:
K. Hamano et al., "Angiogenesis induced by the implantation of self-bone marrow cells: A new material for therapeutic angiogenesis", CELL TRANSP, 9(3), 2000, pp. 439-443

Abstract

Bone marrow contains various primitive cells that are thought to secrete several angiogenic growth factors and may also differentiate into endothelial cells. The present study was conducted to investigate the possibility that bone marrow cells could be a novel material to induce angiogenesis. The expression of vascular endothelial growth factor (VEGF) and basic fibroblastgrowth factor (bFGF) in rat bone marrow cells was examined by immunohistochemistry. The production of VEGF was compared in tissue culture supernatantunder the conditions of normoxia and hypoxia. The process of angiogenesis that occurred following the implantation of bone marrow cells was determined using a rat cornea model. VEGF- and bFGF-positive cells were found in ratbone marrow. The production of VEGF from bone marrow cells was significantly more enhanced by hypoxic conditions than by normoxic conditions. The ratcornea model showed that bone marrow cell implantation created new vessels. The implantation of self-bone marrow cells is a novel and simple method of inducing angiogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 11:27:35