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Titolo:
Changes in atrial electrical properties following cardioversion of chronicatrial fibrillation: relation with recurrence
Autore:
Manios, EG; Kanoupakis, EM; Chlouverakis, GI; Kaleboubas, MD; Mavrakis, HE; Vardas, PE;
Indirizzi:
Univ Hosp Heraklion, Dept Cardiol, Heraklion, Crete, Greece Univ Hosp Heraklion Heraklion Crete Greece iol, Heraklion, Crete, Greece
Titolo Testata:
CARDIOVASCULAR RESEARCH
fascicolo: 2, volume: 47, anno: 2000,
pagine: 244 - 253
SICI:
0008-6363(200008)47:2<244:CIAEPF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTROPHYSIOLOGICAL CHARACTERISTICS; NODE FUNCTION; HUMANS; REFRACTORINESS; MECHANISMS; CONDUCTION; ANESTHESIA; ACTIVATION; VERAPAMIL; PROPOFOL;
Keywords:
atrial function; defibrillation; remodeling; supraventr. arrhythmia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Vardas, PE Univ Hosp Heraklion, Dept Cardiol, POB 1352 Stavrakia, Heraklion, Crete, Greece Univ Hosp Heraklion POB 1352 Stavrakia Heraklion Crete Greece
Citazione:
E.G. Manios et al., "Changes in atrial electrical properties following cardioversion of chronicatrial fibrillation: relation with recurrence", CARDIO RES, 47(2), 2000, pp. 244-253

Abstract

Objective: To study the reversibility of atrial electrical remodeling and its relation with recurrence in post-conversion chronic atrial fibrillation(CAF) patients. Methods: In 28 drug-free CAF patients (mean AF duration 41/-39 months) electrically converted to sinus rhythm effective refractory period (ERP) at 500 ms, monophasic action potential at 90% of repolarization(MAPd90) at five cycle lengths (CL, 350, 400, 450, 500, 600 ms), and P wave duration were measured three times: within the interval 5-20 min post-conversion, 24 h and 1 month later. Fifteen subjects with no history of AF andnormal atrial structure served as a control group. Patients were followed up for recurrence for 1 month; 12 relapsed. Results: ERP changed from 205+/-20 to 243+/-31 to 241+/-24 ms (P<0.001), attaining a level comparable to that of the controls (238+/-21 ms) within 24 h. MAPd90 significantly (P<0.001) increased (from 175+/-11 to 190+/-19 to 191+/-10 ms at CL 350 ms and 201/-12 to 234+/-20 and 233+/-23 ms at CL 600 ms) also reaching control levels within 24 h. MAPd90 exhibited an abnormal adaptation to rate only in the first evaluation. P wave duration was prolonged (137+/-33 ms) and exhibiteda slower course of shortening (130+/-32 to 123+/-27 ms, P<0.001), reachingcontrol levels within 1 month. Patients with higher values of MAPd90 at CL350 in the immediate post-conversion period were more likely to relapse (P<0.005). Conclusions: ERP and repolarization shortening as a result of CAF are reversed within 24 h after conversion, while P wave duration reduces more slowly. Post-conversion MAPd90 values contain prognostic information forrecurrence. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 04:33:04