Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Adrenomedullin inhibits spontaneous and bradykinin-induced but not oxytocin- or prostaglandin F-2 alpha-induced periodic contraction of rat uterus
Autore:
Yanagita, T; Yamamoto, R; Sugano, T; Kobayashi, H; Uezono, Y; Yokoo, H; Shiraishi, S; Minami, S; Wada, A;
Indirizzi:
Miyazaki Med Coll, Dept Pharmacol, Miyazaki 8891692, Japan Miyazaki Med Coll Miyazaki Japan 8891692 rmacol, Miyazaki 8891692, Japan Kyushu Univ Hlth & Welf, Dept Orthopt & Visual Sci, Nobeoka 8828508, JapanKyushu Univ Hlth & Welf Nobeoka Japan 8828508 ci, Nobeoka 8828508, Japan
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 8, volume: 130, anno: 2000,
pagine: 1727 - 1730
SICI:
0007-1188(200008)130:8<1727:AISABB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-LIKE RECEPTOR; GENE-RELATED PEPTIDE; HYPOTENSIVE PEPTIDE; EXPRESSION; PROTEINS; TISSUES; BINDING; SYSTEM; SITES; MOUSE;
Keywords:
adrenomedullin; uterine contraction; calcitonin receptor-like receptor; receptor-activity-modifying protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Wada, A Miyazaki Med Coll, Dept Pharmacol, Miyazaki 8891692, Japan Miyazaki Med Coll Miyazaki Japan 8891692 Miyazaki 8891692, Japan
Citazione:
T. Yanagita et al., "Adrenomedullin inhibits spontaneous and bradykinin-induced but not oxytocin- or prostaglandin F-2 alpha-induced periodic contraction of rat uterus", BR J PHARM, 130(8), 2000, pp. 1727-1730

Abstract

In isolated rat uterine strips, adrenomedullin (AM) inhibited the spontaneous periodic contraction in a concentration-dependent manner (IC50 = 22.3 +/- 0.7 nM). The inhibitory effect of AM was prevented by either AM(22-52), a putative antagonist for AM receptors, or calcitonin gene-related peptide (CGRP)(8-37), a putative antagonist for CGRP receptors. AM also attenuated bradykinin (BK)induced periodic uterine contraction, which was blocked by AM(22-52) or CGRP(8-37), whereas AM had no effect on the periodic contraction caused by oxytocin or prostaglandin F-2 alpha (PGF(2 alpha)). RT-PCR analysis showed that mRNAs for calcitonin receptor-like receptor (CRLR), receptor-activity-modifying protein (RAMP)1, RAMP2 and RAMP3 were expressed in the rat uterus. These results demonstrate that AM selectively inhibits spontaneous and BK-induced periodic contraction via activating receptors for AM and CGRP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:50:03