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Titolo:
Stress-induced relapse to heroin and cocaine seeking in rats: a review
Autore:
Shaham, Y; Erb, S; Stewart, J;
Indirizzi:
NIDA, Behav Neurosci Branch, IRP, NIH, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 sci Branch, IRP, NIH, Baltimore, MD 21224 USA Concordia Univ, Dept Psychol, Ctr Studies Behav Neurobiol, Montreal, PQ H3G 1M8, Canada Concordia Univ Montreal PQ Canada H3G 1M8 l, Montreal, PQ H3G 1M8, Canada
Titolo Testata:
BRAIN RESEARCH REVIEWS
fascicolo: 1, volume: 33, anno: 2000,
pagine: 13 - 33
SICI:
0165-0173(200008)33:1<13:SRTHAC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; SELF-ADMINISTRATION BEHAVIOR; MESSENGER-RNA EXPRESSION; FACTOR-LIKE IMMUNOREACTIVITY; NUCLEUS-ACCUMBENS SHELL; ACOUSTIC STARTLE REFLEX; PITUITARY-ADRENAL AXIS; CENTRAL-NERVOUS-SYSTEM; FREELY-MOVING RATS; STRIA TERMINALIS;
Keywords:
cocaine; heroin; reinstatement; relapse; review; stress;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
221
Recensione:
Indirizzi per estratti:
Indirizzo: Shaham, Y NIDA, Behav Neurosci Branch, IRP, NIH, 5500 Nathan Shock Dr, Baltimore, MD21224 USA NIDA 5500 Nathan Shock Dr Baltimore MD USA 21224 re, MD21224 USA
Citazione:
Y. Shaham et al., "Stress-induced relapse to heroin and cocaine seeking in rats: a review", BRAIN RES R, 33(1), 2000, pp. 13-33

Abstract

Studies in humans suggest that exposure to stress increases the probability of relapse to drug use, bur until recently there has been no animal modelto study the mechanisms that mediate this effect. We have developed a reinstatement procedure that allows us to study the effect of stress on relapseto drug seeking in rats. Using this procedure, we have shown that exposureto intermittent footshock stress reliably reinstates heroin and cocaine seeking after prolonged drug-free periods. In the present paper, we summarizeresults from several studies on stress-induced reinstatement of heroin andcocaine seeking in rats. We first assess the degree to which the phenomenon of stress-induced relapse generalizes to other stressors, to behaviors controlled by other drugs of abuse, and to behaviors controlled by non-drug reinforcers. We then review evidence from studies concerned with the neurotransmitters, the brain sites, and the neural systems involved in stress-induced reinstatement of drug seeking. Finally, we consider the mechanisms thatmight underlie stress-induced relapse to drug seeking and the possible implications of the findings for the treatment of relapse to drug use in humans. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:02:53