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Titolo:
Complications after bone marrow transplantation are manifestations of systemic inflammatory response syndrome
Autore:
Takatsuka, H; Takemoto, Y; Yamada, S; Wada, H; Tamura, S; Fujimori, Y; Okamoto, T; Suehiro, A; Kanamaru, A; Kakishita, E;
Indirizzi:
Hyogo Coll Med, Dept Internal Med 2, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan Kinki Univ, Sch Med, Dept Internal Med 3, Osaka 589, Japan Kinki Univ Osaka Japan 589 ch Med, Dept Internal Med 3, Osaka 589, Japan
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 4, volume: 26, anno: 2000,
pagine: 419 - 426
SICI:
0268-3369(200008)26:4<419:CABMTA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERSUS-HOST DISEASE; THROMBOTIC MICROANGIOPATHY;
Keywords:
allogeneic bone marrow transplantation; systemic inflammatory response syndrome; cytokines; endothelial damage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Takatsuka, H Hyogo Coll Med, Dept Internal Med 2, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med 1-1 Mukogawa Cho Nishinomiya Hyogo Japan 6638501
Citazione:
H. Takatsuka et al., "Complications after bone marrow transplantation are manifestations of systemic inflammatory response syndrome", BONE MAR TR, 26(4), 2000, pp. 419-426

Abstract

Bone marrow transplantation has been established as a useful treatment forvarious hematological disorders and is now performed widely, but the mortality rate is still high due to various complications, A clear therapeutic policy for such complications has not yet been established because of their complex nature. We investigated whether the major complications occurring after bone marrow transplantation could be classified as aspects of the systemic inflammatory response syndrome. Subjects were 10 patients who developed severe complications after bone marrow transplantation (graft-versus-hostdisease, thrombotic microangiopathy, respiratory disorders, and cytomegalovirus interstitial pneumonitis) and 16 patients without complications. Their symptoms, serum cytokines, and factors related to vascular endothelial damage were compared before and after transplantation. Whereas all 10 patients who developed complications had fever in the aplastic phase after transplantation, 15 of the 16 patients without complications remained afebrile (P < 0.001, t-test), When compared with the patients who did not develop complications, the patients with complications also showed significantly higher cytokine levels during the recovery phase after transplantation (P < 0.0001, t-test), Thus, the patients with complications developed fever in the aplastic phase and showed an increase of cytokines during the recovery phase, which triggered the occurrence of vascular endothelial damage shown by factors such as the thrombomodulin and plasminogen activator inhibitor type 1, This sequence of events corresponds with that occurring during systemic inflammatory response syndrome, so many of the complications of bone marrow transplantation can be considered as manifestations of this syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 23:47:53