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Titolo:
Morphometric analysis of renal vessels - Advantage of the multisector areaapproach to cross-sections
Autore:
Woestenburg, AT; Mensch, PP; Bosmans, JL; Elseviers, MM; Verpooten, GA; De Broe, ME;
Indirizzi:
Univ Antwerp, Dept Nephrol, B-2020 Antwerp, Belgium Univ Antwerp AntwerpBelgium B-2020 ept Nephrol, B-2020 Antwerp, Belgium
Titolo Testata:
ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY
fascicolo: 4, volume: 22, anno: 2000,
pagine: 285 - 290
SICI:
0884-6812(200008)22:4<285:MAORV->2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Keywords:
kidney; blood vessels; morphometric analysis; elliptical approach; sector polygon approach; sector circular approach; sector elliptical approach;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Woestenburg, AT Univ Antwerp Hosp, Dept Nephrol Hypertens, Wilrijkstr 10, B-2650 Edegem, Belgium Univ Antwerp Hosp Wilrijkstr 10 Edegem Belgium B-2650 ium
Citazione:
A.T. Woestenburg et al., "Morphometric analysis of renal vessels - Advantage of the multisector areaapproach to cross-sections", ANAL QUAN C, 22(4), 2000, pp. 285-290

Abstract

OBJECTIVE: To determine the most accurate morphometric approach to overcoming the obstacles of limited number, angle of section and irregular contours of vascular structures in analyzing vascular sections of renal biopsies. STUDY DESIGN: The luminal area of 451 cortical arterioles in 65 Masson-trichome-stained renal sections uns assessed with a computer-assisted imaging system connected to a Leica DMR microscope (Mikroskopic und Systeme GmbH, Wetzlar Germany). The luminal area measured by the imaging system was used as the gold standard, against which three mathematical sector approaches andone classical approach were evaluated. The accuracy of these approaches was evaluated by means of the relative deviation from the measured value ann of the degree of overestimation or underestimation. Intraobserver and interobserver variability were determined for the most accurate mathematical approach. RESULTS: As compared to measured luminal area, the sector elliptical approach yielded the lowest relative deviation (13.4 +/- 12.5%), without significant overestimation ol underestimation (-0.6 +/- 18.3%). The intraobserver and interobserver correlation coefficients for this method were 82.3% and 86.5%, respectively. CONCLUSION: The sector elliptical approach is the most accurate mathematical approach to vascular sections in renal biopsies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 18:45:51