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Titolo:
The effect of corticosteroids in the treatment of experimental sinusitis
Autore:
Cable, BB; Wassmuth, Z; Mann, EA; Hommer, D; Connely, G; Klem, C; Quance-Fitch, FJ; Bolger, WE;
Indirizzi:
Walter Reed Army Med Ctr, Dept Surg Otolaryngol, Washington, DC 20307 USA Walter Reed Army Med Ctr Washington DC USA 20307 Washington, DC 20307 USA
Titolo Testata:
AMERICAN JOURNAL OF RHINOLOGY
fascicolo: 4, volume: 14, anno: 2000,
pagine: 217 - 222
SICI:
1050-6586(200007/08)14:4<217:TEOCIT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRAM-NEGATIVE SINUSITIS; RABBITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Cable, BB Walter Reed Army Med Ctr, Dept Otolaryngol, 6825 16th St NW, Washington, DC 20307 USA Walter Reed Army Med Ctr 6825 16th St NW Washington DC USA 20307
Citazione:
B.B. Cable et al., "The effect of corticosteroids in the treatment of experimental sinusitis", AM J RHINOL, 14(4), 2000, pp. 217-222

Abstract

Emerging evidence indicates that medically recalcitrant sinusitis may be associated with a prolonged and excessive state of inflammation rather than a simple bacterial infection. Corticosteroids have been anecdotally reported to be helpful in treating patients with sinusitis; however; there are no scientific studies documenting the safety and efficacy of corticosteroid therapy ill sinusitis. To resolve the controversy over whether corticosteroids promote or inhibit the resolution of sinusitis, we present a prospective study of 80 rabbits with surgically introduced pseudomonal sinusitis that were that treated in one of four arms: control, ceftazidine, methylprednisolone, and ceftazidime with methylprednisolone. Sinus cavities were then evaluated after 5, 14, 21, and 28 days of treatment both by histologic inflammation grading and bacterial quantification. Results showed a significant decrease ill bacterial loads ill both the antibiotic and antibiotic with steroid arms over control animals, although no difference was seen between the two. Histologic grading show ed a similar trend, although statistical significance was not obtained. Overall, this study demonstrated no clear advantage of steroids in the treatment of sinus infections using this model. At thesame point, no significant reduction in the effectiveness of antibiotic therapy was seen with concurrent steroid Else. A number of limitations of theanimal model are noted and the need for human studies in this area is discussed.

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Documento generato il 26/09/20 alle ore 08:59:17