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Titolo:
Sodium homeostasis in transplanted rats with a spontaneously hypertensive rat kidney
Autore:
Frey, BAJ; Grisk, O; Bandelow, N; Wussow, S; Bie, P; Rettig, R;
Indirizzi:
Univ Greifswald, Dept Physiol, D-17495 Karlsburg, Germany Univ GreifswaldKarlsburg Germany D-17495 ol, D-17495 Karlsburg, Germany Odense Univ, Dept Physiol, DK-5000 Odense C, Denmark Odense Univ Odense Denmark C iv, Dept Physiol, DK-5000 Odense C, Denmark
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 3, volume: 279, anno: 2000,
pagine: R1099 - R1104
SICI:
0363-6119(200009)279:3<R1099:SHITRW>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; ENDOTHELIN-1 PRODUCTION; DISEASE PROGRESSION; CONSCIOUS DOGS; BLOOD-PRESSURE; URODILATIN; BALANCE; NATRIURESIS; RELEASE;
Keywords:
hypertension; transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Rettig, R Univ Greifswald, Dept Physiol, Greifswalder Str 11C, D-17495 Karlsburg, Germany Univ Greifswald Greifswalder Str 11C Karlsburg Germany D-17495
Citazione:
B.A.J. Frey et al., "Sodium homeostasis in transplanted rats with a spontaneously hypertensive rat kidney", AM J P-REG, 279(3), 2000, pp. R1099-R1104

Abstract

Recipients of a kidney from spontaneously hypertensive rats (SHR) but not from normotensive Wistar-Kyoto rats (WKY) develop posttransplantation hypertension. To investigate whether renal sodium retention precedes the development of posttransplantation hypertension in recipients of an SHR kidney on a standard sodium diet (0.6% NaCl), we transplanted SHR and WKY kidneys to SHR x WKY F1 hybrids, measured daily sodium balances during the first 12 days after removal of both native kidneys, and recorded mean arterial pressure (MAP) after 8 wk. Recipients of an SHR kidney (n = 12) retained more sodium than recipients of a WKY kidney (n = 12) (7.3 +/- 10 vs. 4.0 +/- 0.7 mmol, P< 0.05). MAP was 144 +/- 6 mmHg in recipients of an SHR kidney and 106 /- 5 mmHg in recipients of a WKY kidney (P< 0.01). Modest sodium restriction (0.2% NaCl) in a further group of recipients of an SHR kidney (n 5 10) did not prevent posttransplantation hypertension (MAP, 142 +/- 4 mmHg). Urinary endothelin and urodilatin excretion rates were similar in recipients ofan SHR and a WKY kidney. Transient excess sodium retention after renal transplantation may contribute to posttransplantation hypertension in recipients of an SHR kidney.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:18:52