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Titolo:
Systolic pressure predicts plasma vasopressin responses to hemorrhage and vena caval constriction in dogs
Autore:
Thrasher, TN; Keil, LC;
Indirizzi:
Univ Maryland, Dept Surg, Baltimore, MD 21201 USA Univ Maryland BaltimoreMD USA 21201 , Dept Surg, Baltimore, MD 21201 USA NASA, Ames Res Ctr, Moffett Field, CA 94035 USA NASA Moffett Field CA USA94035 Ames Res Ctr, Moffett Field, CA 94035 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 3, volume: 279, anno: 2000,
pagine: R1035 - R1042
SICI:
0363-6119(200009)279:3<R1035:SPPPVR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONSCIOUS DOGS; ARTERIAL BARORECEPTORS; RENIN; RECEPTORS; SECRETION; CORTISOL; BLOCKADE; DRINKING; RELEASE; HEART;
Keywords:
antidiuretic hormone; arterial baroreceptors; cardiac receptors; atrial receptors; ventricular receptors; blood volume; blood pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Thrasher, TN Univ Maryland, Dept Surg, 10 S Pine St,Rm 400, Baltimore, MD 21201 USA Univ Maryland 10 S Pine St,Rm 400 Baltimore MD USA 21201 USA
Citazione:
T.N. Thrasher e L.C. Keil, "Systolic pressure predicts plasma vasopressin responses to hemorrhage and vena caval constriction in dogs", AM J P-REG, 279(3), 2000, pp. R1035-R1042

Abstract

We have proposed that the reflex increase in arginine vasopressin (AVP) secretion in response to hypovolemia is due to arterial baroreceptor unloading. If arterial pressure is the key to the mechanism, the slope relating plasma AVP to arterial pressure should be the same in response to hemorrhage, a model of true hypovolemia, and in response to thoracic inferior vena caval constriction (IVCC), a model of central hypovolemia. We tested this hypothesis in conscious, chronically instrumented dogs (n = 8). The mean coefficient of determination (r(2)) values obtained from the individual regressions of log AVP onto systolic pressure (SP) and mean arterial pressure (MAP) in response to hemorrhage were 0.953 +/- 0.009 and 0.845 +/- 0.047, respectively. Paired comparisons indicated a significant difference between the means (P< 0.05), hence, SP was used in subsequent analyses. The mean slopes relating the log of plasma AVP to SP in response to hemorrhage and IVCC were -0.034 +/- 0.003 and -0.032 +/- 0.002, respectively, and the means were notsignificantly different (P = 0.7). The slopes were not altered when the experiments were repeated during acute blockade of cardiac receptors by intrapericardial procaine. Finally, sinoaortic denervation (n = 4) markedly reduced the slope in both the hemorrhage and IVCC treatments. We conclude that baroreceptors monitoring arterial pressure provide the principal reflex control of AVP secretion in response to hypovolemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:55:24