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Titolo:
Norepinephrine mediates glucoprivic-induced increase in GABA in the ventromedial hypothalamus of rats
Autore:
Beverly, JL; De Vries, MG; Beverly, MF; Arseneau, LM;
Indirizzi:
Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 is, Dept Anim Sci, Urbana, IL 61801 USA Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA Univ Illinois Urbana ILUSA 61801 ois, Div Nutr Sci, Urbana, IL 61801 USA Univ Illinois, Program Neurosci, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 Program Neurosci, Urbana, IL 61801 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 3, volume: 279, anno: 2000,
pagine: R990 - R996
SICI:
0363-6119(200009)279:3<R990:NMGIIG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL HYPOTHALAMUS; ENDOGENOUS GABA; FASTED RAT; FEEDING RESPONSE; PREOPTIC AREA; BLOOD-GLUCOSE; FOOD-INTAKE; RELEASE; INSULIN; 2-DG;
Keywords:
microdialysis; 2-deoxy-D-glucose; timolol; yohimbine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Beverly, MF Univ Illinois, Dept Anim Sci, 1207 W Gregory Dr, Urbana, IL 61801 USA Univ Illinois 1207 W Gregory Dr Urbana IL USA 61801 61801 USA
Citazione:
J.L. Beverly et al., "Norepinephrine mediates glucoprivic-induced increase in GABA in the ventromedial hypothalamus of rats", AM J P-REG, 279(3), 2000, pp. R990-R996

Abstract

Noradrenergic mechanisms in the hypothalamus may be involved in counterregulatory responses to glucoprivic episodes. After 2-deoxy-D-glucose (2-DG; 1.2 mmol/kg iv), extracellular norepinephrine (NE) concentration in the ventromedial hypothalamus (VMN) increased in a bimodal fashion to 251 +/- 39% (P < 0.001) and 150 +/- 17% (P < 0.001) of baseline during the first 30 min. In the lateral hypothalamus (LHA), NE decreased by 30 min (61 +/- 4%, P < 0.001) and no consistent changes were measured in the paraventricular nucleus (PVN). Because the NE response in the VMN after 2-DG followed the same pattern as GABA, the interaction between NE and GABA was evaluated. In the VMN, GABA had little effect on extracellular NE concentrations but NE increased GABA concentrations 166 +/- 13%, (P < 0.01). In the presence of yohimbine (alpha(2)-adrenoceptor antagonist) the first GABA peak after 2-DG was absent, and the second GABA peak was absent in the presence of timolol (beta-adrenoceptor antagonist). These results support an interaction among noradrenergic and GABAergic systems in the VMN during glucoprivation and that increased NE mediates the increase in extracellular GABA after 2-DG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:58:32