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Titolo:
Vagal CCK and 5-HT3 receptors are unlikely to mediate LPS or IL-1 beta-induced fever
Autore:
Martin, SM; Wilson, BC; Chen, X; Takahashi, Y; Poulin, P; Pittman, QJ;
Indirizzi:
Univ Calgary, Dept Physiol & Biophys, Neurosci Res Grp, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 s Grp, Calgary, AB T2N 4N1, Canada Mt St Vincent Univ, Halifax, NS B3M 2J6, Canada Mt St Vincent Univ Halifax NS Canada B3M 2J6 Halifax, NS B3M 2J6, Canada
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 3, volume: 279, anno: 2000,
pagine: R960 - R965
SICI:
0363-6119(200009)279:3<R960:VCA5RA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHARMACOLOGICAL CHARACTERIZATION; CHOLECYSTOKININ RECEPTORS; PARAVENTRICULAR NUCLEUS; BRAIN COMMUNICATION; ANESTHETIZED RATS; AFFERENT NEURONS; FOS EXPRESSION; VAGUS NERVE; MAST-CELLS; INTERLEUKIN-1-BETA;
Keywords:
lipopolysaccharide; interleukin; cholecystokinin; serotonin; 5-hydroxytryptamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Pittman, QJ Univ Calgary, Dept Physiol & Biophys, Neurosci Res Grp, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada Univ Calgary 3330 Hosp Dr NW CalgaryAB Canada T2N 4N1 Canada
Citazione:
S.M. Martin et al., "Vagal CCK and 5-HT3 receptors are unlikely to mediate LPS or IL-1 beta-induced fever", AM J P-REG, 279(3), 2000, pp. R960-R965

Abstract

Previous studies suggested that peripheral immune mediators may involve intermediates acting on the vagus nerve, such as CCK or serotonin (5-HT). We have therefore investigated a possible role for vagal CCK-A and 5-HT3 receptors in the febrile response after intraperitoneal human recombinant interleukin-1 beta (IL-1 beta) or lipopolysaccharide (LPS). Unanesthetized, adultmale rats instrumented with abdominal thermistors were given intraperitoneal CCK-8 sulfate (100 or 150 mg/kg) or 2-methyl-5-hydroxytryptamine maleate(4 mg/kg). In other experiments, rats were treated with either antagoniststo the 5-HT3 receptor (ondansetron HCl; 100 mu g/kg) or the CCK-A receptor(L-364,718, 100 or 200 mu g/kg) in combination with LPS or IL-1 beta. CCK administration caused a short-lived hypothermia, but interference with the action of endogenous CCK at CCK-A receptors was without effect on IL-1 beta- or LPS-induced fever. Neither activation of 5-HT3 receptors nor blockade of 5-HT3 receptors affected body temperature or LPS fever. Taken together, our data support the idea that vagal afferents responsive to pyrogenic cytokines may be different from those responsive to CCK or 5-HT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:53:45