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Titolo:
Simian-human immunodeficiency virus-associated nephropathy in macaques
Autore:
Stephens, EB; Tian, CQ; Dalton, SB; Gattone, VH;
Indirizzi:
Univ Kansas, Med Ctr, Dept Microbiol Mol Genet & Immunol, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 & Immunol, Kansas City, KS 66160 USA Univ Kansas, Med Ctr, Dept Anat & Cell Biol, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 Cell Biol, Kansas City, KS 66160 USA
Titolo Testata:
AIDS RESEARCH AND HUMAN RETROVIRUSES
fascicolo: 13, volume: 16, anno: 2000,
pagine: 1295 - 1306
SICI:
0889-2229(200009)16:13<1295:SIVNIM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIV-ASSOCIATED NEPHROPATHY; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; PIG-TAILED MACAQUES; RHESUS MACAQUES; CHEMOKINE RECEPTORS; TRANSGENIC MICE; MOLECULAR CLONE; AIDS DEMENTIA; RENAL-DISEASE; COAT PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Stephens, EB Univ Kansas, Med Ctr, Dept Microbiol Mol Genet & Immunol, 3901 Rainbow Blvd, Kansas City, KS 66160 USA Univ Kansas 3901 Rainbow Blvd Kansas City KS USA 66160 60 USA
Citazione:
E.B. Stephens et al., "Simian-human immunodeficiency virus-associated nephropathy in macaques", AIDS RES H, 16(13), 2000, pp. 1295-1306

Abstract

A number of chimeric simian-human immunodeficiency virus (SHIV) viruses containing tat, rev, vpu, and env from HIV-1 (strain HXBc2) in a genetic background of simian immunodeficiency virus (SIV(mac)239) have been derived from the parental nonpathogenic SHIV-4 virus. In this article we examine the renal pathology associated with the derivation of these pathogenic SHIV strains. The first of the pathogenic SHIVs, SHIVKU-1, is associated with rapid CD4(+) T cell loss and opportunistic infections associated with AIDS, but only one of four infected pigtail macaques examined has developed significant renal pathology. The renal pathology in this macaque consists of a diffuse increase in matrix in the core of each lobule with collapsed glomerular capillries, which is similar to the renal changes reported in HIVAN. Passageof this virus into rhesus macaques yielded SHIVKU-2, which results in renal pathology in three of four inoculated rhesus macaques in which <10% of the glomeruli are involved. A molecular clone of SHIVKU-2 was derived (SHIVKU-2MC4) that causes neurologic and renal pathology with more than 60% of theglomeruli involved and results in uremic level BUN concentrations. These results indicate that SHIVKU-2MC4 causes severe significant glomerular pathology and should permit a detailed analysis of the molecular determinants associated with the development of SHIV-associated glomerulosclerosis in rhesus macaques.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:39:16