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Titolo:
Comparative efficacy of 24-hour and 16-hour transdermal nicotine patches for relief of morning craving
Autore:
Shiffman, S; Elash, CA; Paton, SM; Gwaltney, CJ; Paty, JA; Clark, DB; Liu, KS; Di Marino, ME;
Indirizzi:
Univ Pittsburgh, Smoking Res Grp, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Res Grp, Pittsburgh, PA 15260 USA invivoData Inc, Pittsburgh, PA USA invivoData Inc Pittsburgh PA USAinvivoData Inc, Pittsburgh, PA USA Pinney Associates, Pittsburgh, PA USA Pinney Associates Pittsburgh PA USA inney Associates, Pittsburgh, PA USA
Titolo Testata:
ADDICTION
fascicolo: 8, volume: 95, anno: 2000,
pagine: 1185 - 1195
SICI:
0965-2140(200008)95:8<1185:CEO2A1>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOKING CESSATION; SELF-QUITTERS; TOBACCO; TRIAL; DEPENDENCE; WITHDRAWAL; TIME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Shiffman, S Univ Pittsburgh, Smoking Res Grp, 130 N Bellefield Ave,Suite 510, Pittsburgh, PA 15260 USA Univ Pittsburgh 130 N Bellefield Ave,Suite 510Pittsburgh PA USA 15260
Citazione:
S. Shiffman et al., "Comparative efficacy of 24-hour and 16-hour transdermal nicotine patches for relief of morning craving", ADDICTION, 95(8), 2000, pp. 1185-1195

Abstract

Aims. To compare a transdermal nicotine patch designed for 24-hour wear with one designed for 16-hour wear for relief of craving and withdrawal, particularly in the morning hours. Design. Smokers were randomly assigned to use one of two common patch regimens: NicoDerm/NiQuitin (24-hour wear, 21 mg nicotine) or Nicotrol/Nicorette (16-hour wear, 15 mg). In a double-dummy design, participants wore two patches during the day, one active, one placeboand one patch while sleeping. Setting. A smoking cessation research clinic. Participants. Two hundred and forty-four smokers who suffered morning cravings. Intervention. Two patch formulations approved and marketed for over-the-counter use in the US-NicoDerm CQ (labeled as 21 mg over 24 hours) and Nicotrol (labeled as 15 mg over 16 hours)-were each used according to its instructions. Smokers also received behavioral counseling. Measurements. Fora week of baseline and 2 weeks after quitting, smokers used palm-top computers to assess craving and withdrawal symptoms several times each day. Findings. The 21 mg/24-hour patch yielded consistently better control of craving, not only during the morning hours, but throughout the day, and over the 2-week period of abstinence. Additionally, the 21 mg/24-hour patch yielded greater reductions in anxiety, irritability and restlessness. Smokers usingthe 21 mg/24-hour dosing regimen also experienced longer abstinence than those using the 15 mg/16-hour patch. Conclusions. These findings demonstratethat 24-hour dosing with a 21 mg patch affords superior relief of craving and withdrawal during the first 2 weeks of abstinence, when symptoms are attheir peak, and when relapse is most likely. They confirm the importance of dosing parameters in nicotine replacement products.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/01/21 alle ore 07:58:44