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Titolo:
The effect of prior hypothermia on the physiological response to norepinephrine
Autore:
Weiss, SJ; Muniz, A; Ernst, AA; Lippton, HL; Nick, TG;
Indirizzi:
Univ Calif Davis, Med Ctr, Sect Emergency Med, Div Med, Sacramento, CA 95817 USA Univ Calif Davis Sacramento CA USA 95817 iv Med, Sacramento, CA 95817 USA Virginia Commonwealth Univ, Med Coll Virginia, Dept Emergency Med, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Lung Care Inc, New Orleans, LA USA Lung Care Inc New Orleans LA USALung Care Inc, New Orleans, LA USA Univ Mississippi, Med Ctr, Dept Hlth Sci, University, MS 38677 USA Univ Mississippi University MS USA 38677 th Sci, University, MS 38677 USA
Titolo Testata:
RESUSCITATION
fascicolo: 3, volume: 45, anno: 2000,
pagine: 201 - 207
SICI:
0300-9572(20000801)45:3<201:TEOPHO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; PHARMACOLOGICAL AGENTS; CARDIOPULMONARY BYPASS; ADRENERGIC RESPONSES; RECEPTOR RESERVE; METABOLISM; VEINS; HYPERTHERMIA; TEMPERATURE; ALPHA-1;
Keywords:
hypothermia; catecholamines; cardiac output; norepinephrine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Weiss, SJ Univ Calif Davis, Med Ctr, Sect Emergency Med, Div Med, 2315 Stockton Blvd,PSSB 2100, Sacramento, CA 95817 USA Univ Calif Davis 2315 Stockton Blvd,PSSB 2100 Sacramento CA USA 95817
Citazione:
S.J. Weiss et al., "The effect of prior hypothermia on the physiological response to norepinephrine", RESUSCITAT, 45(3), 2000, pp. 201-207

Abstract

Objective: this study determines the effect of prior hypothermia on the cardiovascular responses to norepinephrine (NE) after rewarming. Methods: theexperiment was a 2 x 2 controlled design with four groups of feline animals. The two variables were the presence or absence of previous cooling, and the use or non-use of NE after rewarming. During the 'cooling' phase, animals were either cooled using an external arterial-venous femoral shunt to 30degrees C or maintained at 37 degrees C. After 'rewarming' animals were stratified to receive either NE at rates to deliver 0.2, 1.0 or 5 mu g/kg perh or normal saline infusions. Animals were instrumented to measure mean arterial pressure (MAP) and cardiac output (CO) and systemic vascular resistance (SVR) was calculated. Results: there were no differences between groupsat baseline and low dose NE (0.2 mu g/kg per min). At 1.0 mu g/kg per min,NE caused a significant increase in CO (P < 0.01) and no effect of MAP or SVR in the rewarmed animals when compared with normothermic controls. In rewarmed animals 5.0 mu g/kg per min NE caused a significant increase in CO (P < 0.01) and no effect on MAP or SVR. In normothermic controls there was asignificant increase in SVR (P = 0.02) and MAP (P = 0.05) and no effect onCO. Conclusion: this study shows that the effect of prior hypothermia on cardiovascular responses to moderate and high doses of NE is an improved CO with no affect on SVR and MAP. This could alter the clinical utility of NE in this situation. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 10:28:28