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Titolo:
Termination of recent-onset atrial fibrillation/flutter in the emergency department: a sequential approach with intravenous ibutilide and external electrical cardioversion
Autore:
Domanovits, H; Schillinger, M; Thoennissen, J; Nikfardjam, M; Janata, K; Brunner, M; Laggner, AN;
Indirizzi:
Univ Vienna, Sch Med, Dept Emergency Med, Vienna Gen Hosp, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 ienna Gen Hosp, A-1090 Vienna, Austria Univ Vienna, Sch Med, Dept Cardiol, Vienna Gen Hosp, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 ienna Gen Hosp, A-1090 Vienna, Austria Univ Vienna, Sch Med, Dept Clin Pharmacol, Vienna Gen Hosp, A-1090 Vienna,Austria Univ Vienna Vienna Austria A-1090 Vienna Gen Hosp, A-1090 Vienna,Austria
Titolo Testata:
RESUSCITATION
fascicolo: 3, volume: 45, anno: 2000,
pagine: 181 - 187
SICI:
0300-9572(20000801)45:3<181:TORAFI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-III AGENT; CONVERSION EFFICACY; SINUS RHYTHM; SUPRAVENTRICULAR TACHYCARDIA; ANTIARRHYTHMIC ACTIONS; FLUTTER; PROCAINAMIDE; FLECAINIDE; SAFETY; MANAGEMENT;
Keywords:
atrial fibrillation/flutter; electrical cardioversion; emergency department; intravenous ibutilide; safety;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Domanovits, H Univ Vienna, Sch Med, Dept Emergency Med, Vienna Gen Hosp, Waehringer Guertel 18-20-6D, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20-6D Vienna Austria A-1090
Citazione:
H. Domanovits et al., "Termination of recent-onset atrial fibrillation/flutter in the emergency department: a sequential approach with intravenous ibutilide and external electrical cardioversion", RESUSCITAT, 45(3), 2000, pp. 181-187

Abstract

Safety and effectiveness are the goals in treating patients with arrhythmias. In an open prospective study, we observed the efficacy and safety of upto 2 mg intravenous ibutilide, a new class III antiarrhythmic agent in haemodynamically stable patients presenting in the emergency department (ED) with symptoms of recent-onset (< 48 h) atrial fibrillation/flutter. Arrhythmia termination within 90 min, haemodynamic parameters and proarrhythmic effects were assessed. Non-responders to the ibutilide infusion underwent external electrical cardioversion. We included 51 patients. In 31 patients therapeutic intervention with intravenous ibutilide was successful within 90 min (61%). In another seven patients conversion to sinus rhythm occurred after 90 min without any other intervention (14%). Blood pressure remained stable and no relevant proarrhythmic effects were observed. The 13 patients whodid not respond to ibutilide treatment underwent successful external electrical cardioversion. The overall conversion rate was 100%. Forty-seven patients (92%) were discharged within a median of 9 h and managed as outpatients. In conclusion, in haemodynamically stable patients with recent-onset atrial fibrillation/flutter intravenous ibutilide and external electrical cardioversion for conversion to sinus rhythm turned out to be effective and safe. The short duration of admission makes this strategy attractive for use in the ED. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:12:29