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Titolo:
Significance of the interleukin-1 receptor antagonist/interleukin-1 beta ratio as a prognostic factor in patients with pulmonary sarcoidosis
Autore:
Mikuniya, T; Nagai, S; Takeuchi, M; Mio, T; Hoshino, Y; Miki, H; Shigematsu, M; Hamada, K; Izumi, T;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Resp Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Resp Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Sangyo Univ, Fac Bioengn, Kyoto, Japan Kyoto Sangyo Univ Kyoto Japan to Sangyo Univ, Fac Bioengn, Kyoto, Japan
Titolo Testata:
RESPIRATION
fascicolo: 4, volume: 67, anno: 2000,
pagine: 389 - 396
SICI:
0025-7931(200007/08)67:4<389:SOTIRA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERSTITIAL LUNG-DISEASES; HUMAN ALVEOLAR MACROPHAGES; ANGIOTENSIN-II RECEPTOR; CONVERTING ENZYME GENE; BALF MACROPHAGES; POLYMORPHISM; ANTAGONIST; GRANULOMA; IL-1; LYMPHOCYTES;
Keywords:
pulmonary sarcoidosis; interleukin-1 beta; interleukin-1 receptor antagonist bronchoalveolar lavage fluid macrophagesangiotensin-converting enzyme activity, serum chest radiographs, shadows; pulmonary function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Nagai, S Kyoto Univ, Grad Sch Med, Dept Resp Med, Sakyo Ku, Kyoto 6068507,Japan Kyoto Univ Kyoto Japan 6068507 , Sakyo Ku, Kyoto 6068507, Japan
Citazione:
T. Mikuniya et al., "Significance of the interleukin-1 receptor antagonist/interleukin-1 beta ratio as a prognostic factor in patients with pulmonary sarcoidosis", RESPIRATION, 67(4), 2000, pp. 389-396

Abstract

Background: Various factors such as serum angiotensin-converting enzyme (sACE) activity, bronchoalveolar lavage (BAL) fluid lymphocyte percent, CD4/CD8 ratio, and shadows on chest radiograph have been identified as indexes of disease activity in patients with sarcoidosis. However, it remains to be confirmed whether these factors can predict clinical outcomes. Objective: To examine whether the interleukin-1 receptor antagonist (IL-1 ra >/ IL-1 beta ratio can predict the clinical course, we prospec tively followed the clinical courses of 30 patients with pulmonary sarcoidosis 4 years after measurement of immunoreactive amounts of IL-1ra or IL-1 beta in the culture supernatants obtained from BAL fluid macrophages. Methods: Immunoreactive amounts of IL-1ra or IL-1 beta were measured using ELISA, Changes in pulmonary function, sACE activity, and shadows on chest radiographs during observation periods were evaluated as markers of changes in disease activity. Results: We found that the patients whose shadows on chest radiographs showed improvement had a higher molar IL-1ra/ IL-1 beta ratio than the patients whose shadows persistently remained 4 years after BAL examination (p < 0.05). Themolar ratio was found to be positively correlated with improvement of percent vital capacity (p < 0.05) and negatively correlated with the ratio of sACE activity at the time of the last observation to sACE activity at the time of BAL (sACE(LAST)/sACE(BAL), p < 0.01) The SACE(LAST)/SACE(BAL) ratio was significantly lower in patients whose shadows on chest radiographs decreased than in those whose shadows remained unchanged (p ( 0.005). Conclusion: The IL-1ra/IL-1 beta ratio in the BAL fluid macrophage culture supernatants in patients with pulmonary sarcoidosis could be a useful marker in predicting the persistence of granulomatous lesions (chronicity). Copyright(C)2000S.KargerAG.Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:01:56