Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Elucidation of the neurobiology of depression: insights from a novel genetic animal model
Autore:
Yadid, G; Nakash, R; Deri, I; Tamer, G; Kinor, N; Gispan, I; Zangen, A;
Indirizzi:
Bar Ilan Univ, Fac Life Sci, Neuropharmacol Sect, IL-52900 Ramat Gan, Israel Bar Ilan Univ Ramat Gan Israel IL-52900 Sect, IL-52900 Ramat Gan, Israel
Titolo Testata:
PROGRESS IN NEUROBIOLOGY
fascicolo: 4, volume: 62, anno: 2000,
pagine: 353 - 378
SICI:
0301-0082(200011)62:4<353:EOTNOD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MILD STRESS; CHRONIC ANTIDEPRESSANT TREATMENT; TRITIATED IMIPRAMINE BINDING; BETA-ENDORPHIN IMMUNOREACTIVITY; PENTOBARBITAL-ANESTHETIZED RAT; INCREASED CHOLINERGIC FUNCTION; SEROTONIN REUPTAKE INHIBITORS; MIDBRAIN DOPAMINERGIC-NEURONS; INESCAPABLE SHOCK INTERFERES; ADRENERGIC-RECEPTOR BINDING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
270
Recensione:
Indirizzi per estratti:
Indirizzo: Yadid, G Bar Ilan Univ, Fac Life Sci, Neuropharmacol Sect, IL-52900 Ramat Gan, Israel Bar Ilan Univ Ramat Gan Israel IL-52900 52900 Ramat Gan, Israel
Citazione:
G. Yadid et al., "Elucidation of the neurobiology of depression: insights from a novel genetic animal model", PROG NEUROB, 62(4), 2000, pp. 353-378

Abstract

Development of drugs for the effective treatment of depressive disorders requires elucidation of factors that are critical for clinically antidepressant effects. During the past 4 years, we have studied in situ neurochemicalalterations in the brain that may underlie depressive behavior. This was achieved using the genetically-selected Flinders Sensitive Line (FSL) of rats (a unique animal model of depression), before and after chronic antidepressant treatment. This line of rats exhibits behavioral features characteristic of depression, and responds to chronic, but not acute, antidepressant treatments. This review summarizes our findings concerning the local neuro-dynamics in the brain during manifestation of depressive behavior and effective antidepressant treatment in this animal model of depression. Understanding the abnormalities manifested in neurochemical pathways during depressive disorders and the dynamic effects of these abnormalities on the onset of action and efficacy of pharmacological treatments are crucial for the development of effective antidepresssant drugs and therapeutic strategies. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:35:27