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Titolo:
The measurement of diffusion and perfusion in biological systems using magnetic resonance imaging
Autore:
Thomas, DL; Lythgoe, MF; Pell, GS; Calamante, F; Ordidge, RJ;
Indirizzi:
Univ Coll London, Sch Med, Inst Child Hlth, RCS Unit Biophys, London WC1N 1EH, England Univ Coll London London England WC1N 1EH ophys, London WC1N 1EH, England Univ Coll London, Dept Med Phys & Bioengn, London WC1E 6JA, England Univ Coll London London England WC1E 6JA oengn, London WC1E 6JA, England Nathan S Kline Inst Psychiat Res, Div Med Phys, Orangeburg, NY 10962 USA Nathan S Kline Inst Psychiat Res Orangeburg NY USA 10962 rg, NY 10962 USA
Titolo Testata:
PHYSICS IN MEDICINE AND BIOLOGY
fascicolo: 8, volume: 45, anno: 2000,
pagine: R97 - R138
SICI:
0031-9155(200008)45:8<R97:TMODAP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; TIME-DEPENDENT DIFFUSION; TRANSIENT FOREBRAIN ISCHEMIA; INTRAVOXEL INCOHERENT MOTION; ANISOTROPIC WATER DIFFUSION; HIGH-RESOLUTION MEASUREMENT; TRACER BOLUS PASSAGES; WEIGHTED MR-IMAGES; APPARENT DIFFUSION; RAT-BRAIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
185
Recensione:
Indirizzi per estratti:
Indirizzo: Thomas, DL Univ Coll London, Sch Med, Inst Child Hlth, RCS Unit Biophys, 30 Guilford St, London WC1N 1EH, England Univ Coll London 30 Guilford St London England WC1N 1EH ngland
Citazione:
D.L. Thomas et al., "The measurement of diffusion and perfusion in biological systems using magnetic resonance imaging", PHYS MED BI, 45(8), 2000, pp. R97-R138

Abstract

The aim of this review is to describe two recent developments in the use of magnetic resonance imaging (MRI) in the study of biological systems: diffusion and perfusion MRI. Diffusion MRI measures the molecular mobility of water in tissue, while perfusion MRI measures the rate at which blood is delivered to tissue. Therefore, both these techniques measure quantities whichhave direct physiological relevance. It is shown that diffusion in biological systems is a complex phenomenon, influenced directly by tissue microstructure, and that its measurement can provide a large amount of information about the organization of this structure in normal and diseased tissue. Perfusion reflects the delivery of essential nutrients to tissue, and so is directly related to its status. The concepts behind the techniques are explained, and the theoretical models that are used to convert MRI data to quantitative physical parameters are outlined. Examples of current applications of diffusion and perfusion MRI are given. In particular, the use of the techniques to study the pathophysiology of cerebral ischaemia/stroke is described. II is hoped that the biophysical insights provided by this approach will help to define the mechanisms of cell damage and allow evaluation of therapies aimed at reducing this damage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 18:29:11