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Titolo:
Optical detection of triggered atherosclerotic plaque disruption by fluorescence emission analysis
Autore:
Christov, A; Dai, E; Drangova, M; Liu, LY; Abela, GS; Nash, P; McFadden, G; Lucas, A;
Indirizzi:
Univ Western Ontario, John P Robarts Res Inst, Vasc Biol Res Labs, London,ON N6A 5K8, Canada Univ Western Ontario London ON Canada N6A 5K8 , London,ON N6A 5K8, Canada John P Robarts Res Inst, Imaging Res Labs, London, ON N6A 5K8, Canada JohnP Robarts Res Inst London ON Canada N6A 5K8 ndon, ON N6A 5K8, Canada Michigan State Univ, Div Cardiol, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 rdiol, E Lansing, MI 48824 USA Univ Western Ontario, Dept Microbiol & Immunol, London, ON, Canada Univ Western Ontario London ON Canada biol & Immunol, London, ON, Canada
Titolo Testata:
PHOTOCHEMISTRY AND PHOTOBIOLOGY
fascicolo: 2, volume: 72, anno: 2000,
pagine: 242 - 252
SICI:
0031-8655(200008)72:2<242:ODOTAP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER-INDUCED FLUORESCENCE; INTRAVASCULAR ULTRASOUND; COHERENCE TOMOGRAPHY; ARTERIAL FLUORESCENCE; RAMAN-SPECTROSCOPY; CORONARY; THROMBOSIS; MODEL; INTERVENTION; LIPOPROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Lucas, A Univ Western Ontario, John P Robarts Res Inst, Vasc Biol Res Labs, 100 Perth Dr,POB 5015, London, ON N6A 5K8, Canada Univ Western Ontario 100 Perth Dr,POB 5015 London ON Canada N6A 5K8
Citazione:
A. Christov et al., "Optical detection of triggered atherosclerotic plaque disruption by fluorescence emission analysis", PHOTOCHEM P, 72(2), 2000, pp. 242-252

Abstract

Fluorescence emission analysis (FEA) has proven to be very sensitive for the detection of elastin, collagen and lipids, which are recognized as the major sources of autofluorescence in vascular tissues. FEA has also been reported to detect venous thromboemboli. In this paper we have tested the hypothesis that FFA can reproducibly detect in vivo and in vitro triggered plaque disruption and thrombosis in a rabbit model. Fluorescence emission (FE) spectra, recorded in vivo, detected Russell's viper venom (RVV)-induced transformation of atherosclerotic plaque. FE intensity at 410-490 nm 4 weeks after angioplasty was significantly lower (P < 0.0033 by analysis of variance) in RVV-treated rabbits when compared to control animals with stable plaque. FE spectral profile analyses also demonstrated a significant change in curve shape as demonstrated by polynomial regression analysis (R-2 from 0.980 to 0.997), We have also demonstrated an excellent correlation between changes in FE intensity and the structural characteristics detected at different stages of "unstable atherosclerotic plaque" development using multiple regression analysis (R-2 = 0.989), Thus, FFA applied in vivo is a sensitiveand highly informative diagnostic technique for detection of triggered atherosclerotic plaque disruption and related structural changes, associated with plaque transformation, in a rabbit model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:04:47