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Titolo:
Patterning of cell assemblies regulated by adhesion receptors of the cadherin superfamily
Autore:
Takeichi, M; Nakagawa, S; Aono, S; Usui, T; Uemura, T;
Indirizzi:
Kyoto Univ, Grad Sch Biostudies, Dept Cell & Dev Biol, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 Dev Biol, Sakyo Ku, Kyoto 6068502, Japan Japan Sci & Technol Corp, PRESTO, Osaka 5650082, Japan Japan Sci & TechnolCorp Osaka Japan 5650082 RESTO, Osaka 5650082, Japan
Titolo Testata:
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
fascicolo: 1399, volume: 355, anno: 2000,
pagine: 885 - 890
SICI:
0962-8436(20000729)355:1399<885:POCARB>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-CATENIN; DROSOPHILA; EXPRESSION; ROLES; OUTGROWTH; MORPHOGENESIS; MOLECULES; COMPLEX; HAIRS;
Keywords:
adhesion molecule; cadherin; Flamingo; neural crest; p120(ctn);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Takeichi, M Kyoto Univ, Grad Sch Biostudies, Dept Cell & Dev Biol, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 akyo Ku, Kyoto 6068502, Japan
Citazione:
M. Takeichi et al., "Patterning of cell assemblies regulated by adhesion receptors of the cadherin superfamily", PHI T ROY B, 355(1399), 2000, pp. 885-890

Abstract

During morphogenesis, cell cell association patterns are dynamically altered. We are interested in how ce adhesion molecule scan regulate the patterning of cellular assemblies. Cadherins, a group of cell-cell adhesion receptors, are crucial for the organized assembly of many cell types, but they also regulate dynamic aspects of cell association. For example, during neuralcrest emigration from the neural tube, the cadherin subtypes expressed by crest cells ar switched from one subtype to another. Artificial perturbation of this switch results in blocking of their escape from the neural tube. Intracellular modulations of cadherin activity also seem to play a role in regulation of cell adhesion. We identified p120(ctn) as a regulator of cadherin function in carcinoma cells. With such regulators, cells may make a choice as to whether they should maintain stable cell contacts or disrupt their association. Finally, we found another type of cadherin-mediated cell patterning: Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity in Drosophila imaginal discs. Thus, the cadherin superfamily receptors control the patterning of cell assemblies through a variety of mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:40:10