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Titolo:
Pretransplant blood transfusions with cyclosporine in pediatric renal transplantation
Autore:
Niaudet, P; Dudley, J; Charbit, M; Gagnadoux, MF; Macleay, K; Broyer, M;
Indirizzi:
Hop Necker Enfants Malad, Dept Pediat Nephrol, F-75015 Paris, France Hop Necker Enfants Malad Paris France F-75015 rol, F-75015 Paris, France
Titolo Testata:
PEDIATRIC NEPHROLOGY
fascicolo: 6, volume: 14, anno: 2000,
pagine: 451 - 456
SICI:
0931-041X(200006)14:6<451:PBTWCI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
KIDNEY-GRAFT-SURVIVAL; DONOR-SPECIFIC TRANSFUSION; ANTIIDIOTYPIC ANTIBODIES; ALLOGRAFT RECIPIENTS; CLONAL DELETION; RATS; HLA;
Keywords:
blood transfusion; cyclosporine; renal transplantation; cytotoxic antibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Niaudet, P Hop Necker Enfants Malad, Dept Pediat Nephrol, 149 Rue Sevres, F-75015 Paris, France Hop Necker Enfants Malad 149 Rue Sevres Paris FranceF-75015 e
Citazione:
P. Niaudet et al., "Pretransplant blood transfusions with cyclosporine in pediatric renal transplantation", PED NEPHROL, 14(6), 2000, pp. 451-456

Abstract

Pretransplant transfusions were repeatedly shown to be associated with improved graft survival in the "pre-cyclosporine era," and have recently been shown to be beneficial in patients on modern immunosuppressive regimes. In an attempt to improve this transfusion effect and minimize the potential development of cytotoxic antibodies, we have given these transfusions, with concomitant cyclosporine cover, prior to transplantation. Ninety-two renal transplantations were performed in 91 children in the study group (group 1) and all received pretransplant transfusions with cyclosporine cover. Results were compared with a preceding group of 102 children (104 transplantations) who had received pretransplant transfusions without cyclosporine cover (group 2). There were 70 cadaver and 22 living-related donor (LRD) transplants in group 1, and 88 cadaver and 16 LRD transplants in group 2. Graft survival rates (1-and 5-year) for cadaver transplantation were 96% and 90% in group 1 compared with 78% and 64% in group 2 (P=0.001). For LRD transplantation, these figures were 95% and 87% in group 1 and 81% and 69% in group 2. There was no difference between the two groups in terms of age at transplantation, sex, donor age, HLA-A, -B, -DR mismatches, or cold and warm ischemia times. All cadaver graft recipients received quadruple, sequential immunosuppression post transplant. However, 9 patients in group 1 were changed totacrolimus for recurrent rejection episodes. No patient developed persistent lymphocytotoxic antibodies post transfusion or side effects of cyclosporine. Cyclosporine can be safely given with whole blood prior to transplantation with no adverse effect and no sensitization. Graft survival was significantly improved in this group of patients and graft loss due to rejection was exceptional. This effect should be further evaluated in prospective studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:18:50