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Titolo:
Plasma and tissue levels of tea catechins in rats and mice during chronic consumption of green tea polyphenols
Autore:
Kim, SB; Lee, MJ; Hong, JI; Li, C; Smith, TJ; Yang, GY; Seril, DN; Yang, CS;
Indirizzi:
Rutgers State Univ, Coll Pharm, Canc Res Lab, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 Lab, Piscataway, NJ 08854 USA
Titolo Testata:
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
fascicolo: 1, volume: 37, anno: 2000,
pagine: 41 - 48
SICI:
0163-5581(2000)37:1<41:PATLOT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED COLON CARCINOGENESIS; A/J MICE; LUNG TUMORIGENESIS; BLACK TEA; N-NITROSODIETHYLAMINE; TUMOR INITIATION; INHIBITION; CANCER; FLAVONOIDS; ABSORPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, SB Rutgers State Univ, Coll Pharm, Canc Res Lab, 164 Frelinghuysen Rd, Piscataway, NJ 08854 USA Rutgers State Univ 164 Frelinghuysen Rd Piscataway NJ USA 08854 SA
Citazione:
S.B. Kim et al., "Plasma and tissue levels of tea catechins in rats and mice during chronic consumption of green tea polyphenols", NUTR CANCER, 37(1), 2000, pp. 41-48

Abstract

To understand the relationship between tea consumption and its biological effects, plasma and tissue levels of (-)-epigallocatechin-3-gallate (EGCG),(-)-epigallocatechin (EGC), and (-)-epicatechin (EC) were measured after rats and mice were given a 0.6% green tea polyphenol preparation as the drinking fluid for different periods of time. EGC and EC levels in rat plasma increased over time and reached peak values (3 times the Day 1 values) on Day 14. Then the plasma levels of tea catechins decreased, to Day I values onDay 28. The plasma concentrations of EGCG were much lower than those of EGC or EC. High levels of EGC and EC were found in urine whereas high levels of EGCG were found in feces. The changes in the urinary and fecal excretions of tea catechins could not account for the above-described changes in theplasma levels. The amounts of catechins in different tissues reflected theingestion, absorption, and excretion pattern. When the green tea polyphenol preparation was given to mice, the "increaseand-then-decrease" pattern ofcatechin levels was also observed in the plasma, lung, and liver; the EGCGlevels were much higher than in the rats. The results suggest that consumption of tea by rodents could induce adaptive responses affecting blood and tissue levels of tea catechins with time and that investigation of a similar phenomenon in humans is warranted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 17:24:08