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Titolo:
Effects of selective serotonin reuptake inhibitors on objective and subjective sleep quality
Autore:
Oberndorfer, S; Saletu-Zyhlarz, G; Saletu, B;
Indirizzi:
Univ Vienna, Sch Med, Dept Psychiat, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Dept Psychiat, A-1090 Vienna, Austria
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 2, volume: 42, anno: 2000,
pagine: 69 - 81
SICI:
0302-282X(2000)42:2<69:EOSSRI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELDERLY DEPRESSED-PATIENTS; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; MAJOR DEPRESSION; REM-SLEEP; HEALTHY-VOLUNTEERS; QUANTITATIVE EEG; NREM SLEEP; FLUOXETINE; NEFAZODONE;
Keywords:
selective serotonin reuptake inhibitor; objective sleep quality; subjective sleep quality; polysomnography; nefazodone; trazodone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Saletu, B Univ Vienna, Sch Med, Dept Psychiat, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 ustria
Citazione:
S. Oberndorfer et al., "Effects of selective serotonin reuptake inhibitors on objective and subjective sleep quality", NEUROPSYCHB, 42(2), 2000, pp. 69-81

Abstract

The purpose of this paper is to review the effects of selective serotonin (5-HT) reuptake inhibitors on objective and subjective sleep and awakening quality measures. Polysomnography (PSG) demonstrated in both healthy volunteers and depressed patients a decrease in sleep efficiency and total sleep time, a lengthening of sleep latency and a deterioration in sleep continuity, including an increase in the number of awakenings and wake time during the total sleep period. Sleep architecture mostly showed an increase in S1 and S2 and a decrease in S3, S4 and REM sleep as well as a lengthening of REM latency. Objective awakening quality, if measured at all by psychometry, generally showed no decrements. Concerning subjective sleep and awakening quality, normals demonstrated either no changes or a tendency towards a deterioration, while in patients some improvement was observed. Reasons for th is discrepancy will be discussed. Novel 5-HT reuptake inhibitors with additional modes of action such as 5-HT2 antagonism (e.g. trazodone, nefazodone)are more likely to improve objective and subjective sleep quality, although some shortcomings may be inherent in regard to comorbidity (e.g. sleep-related breathing disorders). Thus, PSG seems to be a necessity for diagnosisand treatment of complex sleep disorders. Copyright (C) 2000 S. Karger AG,Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:29:08