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Titolo:
High density of long dinucleotide microsatellites in Drosophila subobscura
Autore:
Pascual, M; Schug, MD; Aquadro, CF;
Indirizzi:
Univ Barcelona, Dept Genet, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 t Genet, E-08028 Barcelona, Spain Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 t Mol Biol & Genet, Ithaca, NY 14853 USA
Titolo Testata:
MOLECULAR BIOLOGY AND EVOLUTION
fascicolo: 8, volume: 17, anno: 2000,
pagine: 1259 - 1267
SICI:
0737-4038(200008)17:8<1259:HDOLDM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUTATION-RATES; GENE REGION; MELANOGASTER; POPULATIONS; EVOLUTION; LOCI; COLONIZATION; POLYMORPHISM; MADEIRENSIS; SIMULANS;
Keywords:
microsatellites; Drosophila subobscura; variation; mutation rate; effective population size;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Pascual, M Univ Barcelona, Dept Genet, Diagonal 645, E-08028 Barcelona, Spain Univ Barcelona Diagonal 645 Barcelona Spain E-08028 ona, Spain
Citazione:
M. Pascual et al., "High density of long dinucleotide microsatellites in Drosophila subobscura", MOL BIOL EV, 17(8), 2000, pp. 1259-1267

Abstract

We isolated 96 dinucleotide repeats with five or more tandemly repeated units from a subgenomic Drosophila subobscura library. The mean repeat unit length of microsatellite clones in D. subobscura is 15, higher than that observed in other Drosophila species. Population variation was assayed in 32-40 chromosomes from Barcelona, Spain, using 18 randomly chosen microsatellite loci. Positive correlation between measures of variation and perfect repeat length measures (mean size, most common, and longest allele) is consistent with a higher mutation rate in loci with longer repeat units. Levels of microsatellite variation measured as variance in repeat number and heterozygosity in D. subobscura were similar to those of Drosophila pseudoobscura and higher than those of Drosophila melanogaster and Drosophila simulans. Our data suggest that higher levels of microsatellite variation, and possiblydensity, in D. subobscura compared with D. melanogaster are due to both a higher average effective population and a higher intrinsic slippage rate inthe former species.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:15:07