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Titolo:
Functional magnetic resonance imaging with intermolecular multiple-quantumcoherences
Autore:
Richter, W; Richter, M; Warren, WS; Merkle, H; Andersen, P; Adriany, G; Ugurbil, K;
Indirizzi:
Natl Res Council Canada, Inst Biodiagnost, Winnipeg, MB R3B 1Y6, Canada Natl Res Council Canada Winnipeg MB Canada R3B 1Y6 eg, MB R3B 1Y6, Canada Univ Minnesota, Ctr Magnet Resonance Res, Minneapolis, MN USA Univ Minnesota Minneapolis MN USA net Resonance Res, Minneapolis, MN USA Princeton Univ, Dept Chem, Princeton, NJ 08544 USA Princeton Univ Princeton NJ USA 08544 Dept Chem, Princeton, NJ 08544 USA
Titolo Testata:
MAGNETIC RESONANCE IMAGING
fascicolo: 5, volume: 18, anno: 2000,
pagine: 489 - 494
SICI:
0730-725X(200006)18:5<489:FMRIWI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORY STIMULATION;
Keywords:
fMRI; intermolecular multiple quantum coherences; brain function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Richter, W Natl Res Council Canada, Inst Biodiagnost, 435 Ellice Ave, Winnipeg, MB R3B 1Y6, Canada Natl Res Council Canada 435 Ellice Ave Winnipeg MBCanada R3B 1Y6
Citazione:
W. Richter et al., "Functional magnetic resonance imaging with intermolecular multiple-quantumcoherences", MAGN RES IM, 18(5), 2000, pp. 489-494

Abstract

For the first time, we demonstrate here functional magnetic resonance imaging (fMRI) using intermolecular multiple-quantum coherences (iMQCs). iMQCs are normally not observed in liquid-state NMR because dipolar interactions between spins average to zero. If the magnetic isotropy of the sample is broken through the use of magnetic field gradients, dipolar couplings dan reappear, and hence iMQCs can be observed. Conventional (BOLD) fMRI measures susceptibility variations averaged over each voxel. In the experiment performed here, the sensitivity of iMQCs to frequency variations over mesoscopic and well-defined distances is exploited. We show that iMQC contrast is qualitatively and quantitatively different from BOLD contrast in a visual stimulation task. While the number of activated pixels is smaller in iMQC contrast, the intensity change in some pixels exceeds that of BOLD contrast severalfold. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 02:34:19