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Titolo:
Cytoplasmic cytokines in lymphoproliferative disorders: Multiple cytokine production in angioimmunoblastic lymphadenopathy with dysproteinemia
Autore:
Ohshima, K; Haraoka, S; Suzumiya, J; Kawasaki, C; Kanda, M; Kikuchi, M;
Indirizzi:
Fukuoka Univ, Sch Med, Dept Pathol, Jonan Ku, Fukuoka 81401, Japan FukuokaUniv Fukuoka Japan 81401 Pathol, Jonan Ku, Fukuoka 81401, Japan
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 5-6, volume: 38, anno: 2000,
pagine: 541 - 545
SICI:
1042-8194(200008)38:5-6<541:CCILDM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIO-IMMUNOBLASTIC LYMPHADENOPATHY; B-CELL LYMPHOMAS; PATHOGENIC SIGNIFICANCE; CYCLOSPORINE-A; INTERLEUKIN-6; RECEPTOR; SERUM; IL-6;
Keywords:
angioimmunoblastic lymphadenopatly with dysproteinemia; AILD; cytokines; cytoplasmic cytokines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Ohshima, K Fukuoka Univ, Sch Med, Dept Pathol, Jonan Ku, Nanakuma 7-45-1, Fukuoka 81401, Japan Fukuoka Univ Nanakuma 7-45-1 Fukuoka Japan 81401 81401, Japan
Citazione:
K. Ohshima et al., "Cytoplasmic cytokines in lymphoproliferative disorders: Multiple cytokine production in angioimmunoblastic lymphadenopathy with dysproteinemia", LEUK LYMPH, 38(5-6), 2000, pp. 541-545

Abstract

Cytokines play an important role in the pathogenesis of lymphomas via autocrine or paracrine mechanisms, or both. Here we determined the proportion of CD3-positive T lymphocytes containing various types of cytokines in enlarged lymph nodes. Lymph nodes were obtained from 16 patients with various lymphoproliferative disorders, including 3 cases with angioimmunoblastic lymphadenopathy with dysproteinemia (AILD), 3 cases with adult T cell leukemia/lymphoma (ATLL), 2 cases with T-cell nonspecific malignant lymphoma (T-ML),3 cases with B-cell diffuse large malignant lymphoma (BDL), 3 cases with histiocytic necrotizing lymphadenitis (HNL), and 2 cases with non-specific lymphadenitis (NSL), The percentages of T lymphocytes positive for cytoplasmic cytokines IL-2, IL-4, IL-5, IL-6, IL-13, TNF-alpha, and INF-gamma were determined. The percentage of INF-gamma positive T lymphocytes was high in reactive lymphadenopathy of NSL and HNL. AILD showed a high proportion of TNF-alpha positive T-lymphocytes, and in addition, the percentages of IL-2, IL-4, IL-5, IL-6, IL-13 and INF-gamma positive T-lymphocytes were relativelyhigher than in other diseases. Our results supported the state of multiplehypercytokinemia typically seen in AILD and suggested that the source of the cytokines is the lymph nodes. Our results also suggested that multiple cytokine networks play an important role in the clinical and histopathological features of AILD. Modulation of the cytokine network may be the logical objective in future therapeutic strategies designed for AILD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 23:46:54