Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Facile syntheses of building blocks for the construction of phosphotyrosine mimetics
Autore:
Cockerill, GS; Easterfield, HJ; Percy, JM; Pintat, S;
Indirizzi:
Glaxo Wellcome Med Res Ctr, Stevenage SG1 2NY, Herts, England Glaxo Wellcome Med Res Ctr Stevenage Herts England SG1 2NY Herts, England Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England
Titolo Testata:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
fascicolo: 16, , anno: 2000,
pagine: 2591 - 2599
SICI:
1470-4358(2000):16<2591:FSOBBF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE-PHOSPHATASE 1B; STRUCTURE-BASED DESIGN; CROSS-COUPLING REACTIONS; SRC SH2 INHIBITORS; ELECTROPHILIC FLUORINATION; GRB2-SH2 DOMAIN; LIGANDS; DISCOVERY; PEPTIDE; DERIVATIVES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Cockerill, GS Glaxo Wellcome Med Res Ctr, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England Glaxo Wellcome Med Res Ctr Gunnels Wood Rd Stevenage Herts England SG1 2NY
Citazione:
G.S. Cockerill et al., "Facile syntheses of building blocks for the construction of phosphotyrosine mimetics", J CHEM S P1, (16), 2000, pp. 2591-2599

Abstract

The copper-catalysed zinc phosphonate chemistry described by Yokomatsu andShibuya can be used to enter the classical organometallic coupling repertoire via Stille and Suzuki-Miyaura couplings. 1,4-Diiodobenzene underwent coupling with the organozinc reagent derived from diethyl bromodifluoromethylphosphonate with copper(I) catalysis to afford diethyl (4-iodophenyl)difluoromethylphosphonate. Higher yielding couplings were run with (4-trifluoromethylsulfonyloxy)- and (4-nonafluorobutylsulfonyloxy)-iodobenzenes. The iodide and the triflate coupled under palladium-catalysed conditions with a range of stannanes and boronic acids in moderate to excellent yields. Shibuya-Yokomatsu couplings were also successful with more functionalised iodoarenes and heteroarenes presenting the important phosphate mimic on a range of scaffolds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:13:43