Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The weaver mutation reverses the function of dopamine and GABA in mouse dopaminergic neurons
Autore:
Guatteo, E; Fusco, FR; Giacomini, P; Bernardi, G; Mercuri, NB;
Indirizzi:
Ist Ricovero & Cura Carattere Sci, Fdn Santa Lucia, Lab Expt Neurol, I-00179 Rome, Italy Ist Ricovero & Cura Carattere Sci Rome Italy I-00179 I-00179 Rome, Italy Univ Roma Tor Vergata, Neurol Clin, I-00173 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00173 eurol Clin, I-00173 Rome, Italy Univ Rome La Sapienza, Neurol Clin, I-00161 Rome, Italy Univ Rome La Sapienza Rome Italy I-00161 eurol Clin, I-00161 Rome, Italy
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 16, volume: 20, anno: 2000,
pagine: 6013 - 6020
SICI:
0270-6474(20000815)20:16<6013:TWMRTF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR GRANULE CELLS; SUBSTANTIA-NIGRA NEURONS; ACTIVATED CATION CURRENT; VENTRAL TEGMENTAL AREA; MUTANT MICE; K+ CHANNEL; POTASSIUM CHANNELS; I-H; RAT; GIRK2;
Keywords:
substantia nigra; dopamine; baclofen; inwardly rectifying K+ channels; weaver mouse; electrophysiology; dopamine-related disorders;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Mercuri, NB Ist Ricovero & Cura Carattere Sci, Fdn Santa Lucia, Lab Expt Neurol, Via Ardeatina 306, I-00179 Rome, Italy Ist Ricovero & Cura CarattereSci Via Ardeatina 306 Rome Italy I-00179
Citazione:
E. Guatteo et al., "The weaver mutation reverses the function of dopamine and GABA in mouse dopaminergic neurons", J NEUROSC, 20(16), 2000, pp. 6013-6020

Abstract

In the present study, we characterized the intrinsic electrophysiological properties and the membrane currents activated by dopamine (DA) D-2 and GABA(B) receptors in midbrain dopaminergic neurons, maintained in vitro in a slice preparation, from wild-type and homozygous weaver (wv/wv) mice. By using patch-clamp techniques, we found that membrane potential, apparent inputresistance, and spontaneous firing of wv/wv dopaminergic neurons were similar to those of dopamine-containing cells recorded from nonaffected (+/+) animals. More interestingly, the wv/wv neurons were excited rather than inhibited by dopamine and the GABA(B) agonist baclofen. This neurotransmitter-mediatedexcitation was attributable to the activation of a G-protein-gated inward current that reversed polarity at a membrane potential of approximately -30mV. We suggest that the altered behavior of the receptor-operated wv G-protein-gated inwardly rectifying K+ channel 2 (GIRK2) might be related to theselective degeneration of the dopaminergic neurons. In addition, the wv GIRK2 would not only suppress the autoreceptor-mediated feedback inhibition of DA release but could also establish a feedforward mechanism of DA releasein the terminal fields.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:42:44