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Titolo:
Octreotide inhibits the enterochromaffin-like cell but not peroxisome proliferator-induced hypergastrinemia
Autore:
Bakke, I; Sandvik, AK; Waldum, HL;
Indirizzi:
Norwegian Univ Sci & Technol, Fac Med, Dept Physiol & Biomed Engn, N-7489 Trondheim, Norway Norwegian Univ Sci & Technol Trondheim Norway N-7489 9 Trondheim, Norway Univ Trondheim Hosp, Dept Med, N-7006 Trondheim, Norway Univ Trondheim Hosp Trondheim Norway N-7006 ed, N-7006 Trondheim, Norway
Titolo Testata:
JOURNAL OF MOLECULAR ENDOCRINOLOGY
fascicolo: 1, volume: 25, anno: 2000,
pagine: 109 - 119
SICI:
0952-5041(200008)25:1<109:OITECB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMATOSTATIN ANALOG OCTREOTIDE; GASTRIN GENE-EXPRESSION; PERFUSED RAT STOMACH; ANTRAL GASTRIN; HISTAMINE-RELEASE; ENDOCRINE-CELLS; OXYNTIC MUCOSA; ACID-SECRETION; CIPROFIBRATE; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Bakke, I Norwegian Univ Sci & Technol, Fac Med, Dept Physiol & Biomed Engn, N-7489 Trondheim, Norway Norwegian Univ Sci & Technol Trondheim Norway N-7489 im, Norway
Citazione:
I. Bakke et al., "Octreotide inhibits the enterochromaffin-like cell but not peroxisome proliferator-induced hypergastrinemia", J MOL ENDOC, 25(1), 2000, pp. 109-119

Abstract

The peroxisome proliferator ciprofibrate induces hypergastrinemia and as aconsequence, enterochromaffin-like (ECL) cell hyperplasia. The mechanism for the gastrin cell stimulation is unknown. The somatostatin analog octreotide LAR (long-acting release) was used to see if the stimulating effects ofciprofibrate could be attenuated. Female Fischer rats were dosed with ciprofibrate (50 mg/kg body weight per day) alone or combined with octreotide LAR (10 mg/30 days) for 60 days. Plasma gastrin and histamine, gastric endocrine cell densities and mRNA abundances were measured. Ciprofibrate increased gastrin mRNA abundance (P<0.05), gastrin cell number (<0.001) and cell area (P<0.01), and induced hypergastrinemia (P<0.001). These rats had profound ECL cell hyperplasia, confirmed by an increase in chromogranin A (CgA) and histidine decarboxylase (HDC) mRNA, density of neuroendocrine and ECL cells and plasma histamine levels (all P<0.001). Octreotide LAR did not affect ciprofibrate stimulation of gastrin cells, but all parameters of ECL cellhyperplasia were reduced (P<0.001). Octreotide LAR also significantly inhibited basal ECL cell function and growth. Ciprofibrate stimulates gastrin cell activity by a mechanism unaffected by octreotide, but octreotide does inhibit basal and gastrin-stimulated ECL cell function and growth.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:07:09