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Titolo:
Is systolic pressure a better target for antihypertensive treatment than diastolic pressure?
Autore:
Leonetti, G; Cuspidi, C; Facchini, M; Stramba-Badiale, M;
Indirizzi:
Osped San Luca, IRCCS, I-20149 Milan, Italy Osped San Luca Milan Italy I-20149 San Luca, IRCCS, I-20149 Milan, Italy Ist Auxolog Italiano, Milan, Italy Ist Auxolog Italiano Milan ItalyIst Auxolog Italiano, Milan, Italy Univ Milan, Med Clin, Milan, Italy Univ Milan Milan ItalyUniv Milan, Med Clin, Milan, Italy
Titolo Testata:
JOURNAL OF HYPERTENSION
, volume: 18, anno: 2000, supplemento:, 3
pagine: S13 - S20
SICI:
0263-6352(200007)18:<S13:ISPABT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; STAGE RENAL-DISEASE; BLOOD-PRESSURE; ACTIVE TREATMENT; PULSE PRESSURE; OLDER PATIENTS; HYPERTENSION; STROKE; RISK; FRAMINGHAM;
Keywords:
systolic and diastolic blood pressure; cardiovascular risk; isolated systolic hypertension; elderly;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Leonetti, G Osped San Luca, IRCCS, Via Spagnoletto, I-20149 Milan, Italy Osped San Luca Via Spagnoletto Milan Italy I-20149 lan, Italy
Citazione:
G. Leonetti et al., "Is systolic pressure a better target for antihypertensive treatment than diastolic pressure?", J HYPERTENS, 18, 2000, pp. S13-S20

Abstract

Background Diastolic blood pressure has been evaluated in different prospective cohort studies and in pharmacological intervention trials, which haveshown the increased risk of cardiovascular events in hypertensive patientsand the benefits of antihypertensive therapy. Aims To show that systolic blood pressure is at least as important as, or even more important than, diastolic blood pressure as a risk factor for cardiovascular complications. Methods Review of medical literature. Results Large epidemiological trials such as the Multiple Risk Factors Intervention Trial (MRFIT) and the Framingham study have shown that systolic blood pressure is an independent, continuous and modifiable risk for all cardiovascular complications. and in elderly subjects isolated systolic hypertension is the most frequent form of hypertension. In elderly subjects the increased stiffness of large arteries is responsible for the early reflection of pulse wave and for the decrease in diastolic blood pressure due to reduced recoil of large arteries. This is summarized in the increase in pulse pressure, which is directly related to the risk of cardiovascular complications. Three large intervention trials in elderly patients with isolated systolic hypertension have shown the relevant cardiovascular benefit of pharmacological reduction of elevated systolic blood pressure and normal diastolic values: the cardiovascular benefit is similar to that found in the general hypertensive population and in elderly patients with systolic-diastolic hypertension. Conclusion Systolic blood pressure represents an important risk factor forcardiovascular events which can be prevented or reduced with pharmacological treatment. (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 04:42:24