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Titolo:
BLTR mediates leukotriene B-4-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis
Autore:
Tager, AM; Dufour, JH; Goodarzi, K; Bercury, SD; von Andrian, UH; Luster, AD;
Indirizzi:
Harvard Univ, Massachusetts Gen Hosp, Sch Med,Div Rheumatol Allergy & Immunol, Ctr Immunol & Inflammatoy Dis, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 & Inflammatoy Dis, Boston, MA 02114 USA Ctr Blood Res, Boston, MA 02115 USA Ctr Blood Res Boston MA USA 02115Ctr Blood Res, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pathol, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 3, volume: 192, anno: 2000,
pagine: 439 - 446
SICI:
0022-1007(20000807)192:3<439:BMLBCA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-4; RECEPTOR; INFLAMMATION; ANTAGONIST; MONOCYTES; PATHWAY; POTENT; MICE;
Keywords:
receptors; leukotriene; chemotactic factors; inflammation mediators; knockout;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Luster, AD Massachusetts Gen Hosp, Bldg 149,13th St, Charlestown, MA 02129USA Massachusetts Gen Hosp Bldg 149,13th St Charlestown MA USA 02129
Citazione:
A.M. Tager et al., "BLTR mediates leukotriene B-4-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis", J EXP MED, 192(3), 2000, pp. 439-446

Abstract

Leukotriene B-4 (LTB4) is a potent chemoattractant active on multiple leukocytes. including neutrophils, macrophages, and eosinophils, and is implicated in the pathogenesis of a variety of inflammatory processes. A seven transmembrane-spanning, G protein-coupled receptor, called BLTR (LTB4 receptor), has recently been identified as an LTB4 receptor. To determine if BLTR is the sole receptor mediating LTB4-induced leukocyte activation and to determine the role of LTB4 and BLTR in regulating leukocyte function in inflammation in vivo, we generated a BLTR-deficient mouse by targeted gene disruption. This mouse reveals that BLTR alone is responsible for LTB4-mediated leukocyte calcium flux, chemotaxis, and firm adhesion to endothelium in vivo. Furthermore, despite the apparent functional redundancy with other chemoattractant-receptor pairs in vitro, LTB4 and BLTR play an important role in the recruitment and/or retention of leukocytes, particularly eosinophils, tothe inflamed peritoneum in vivo. These studies demonstrate that BLTR is the key receptor that mediates LTB4-induced leukocyte activation and establishes a model to decipher the functional roles of BLTR and LTB4 in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:21:03