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Titolo:
A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo
Autore:
Taylor, PR; Carugati, A; Fadok, VA; Cook, HT; Andrews, M; Carroll, MC; Savill, JS; Henson, PM; Botto, M; Walport, MJ;
Indirizzi:
Hammersmith Hosp, Imperial Coll, Sch Med, Div Med,Rheumatol Sect, London W12 0NN, England Hammersmith Hosp London England W12 0NN ol Sect, London W12 0NN, England Hammersmith Hosp, Imperial Coll, Sch Med, Dept Histopathol, London W12 0NN, England Hammersmith Hosp London England W12 0NN opathol, London W12 0NN, England Natl Jewish Med Res Ctr, Dept Pediat, Denver, CO 80206 USA Natl Jewish MedRes Ctr Denver CO USA 80206 Pediat, Denver, CO 80206 USA Univ Nottingham Hosp, Div Renal & Inflammatory Dis, Nottingham NG7 2UH, England Univ Nottingham Hosp Nottingham England NG7 2UH tingham NG7 2UH, England Harvard Univ, Sch Med, Dept Pediat, Ctr Blood Res, Boston, MA 02165 USA Harvard Univ Boston MA USA 02165 iat, Ctr Blood Res, Boston, MA 02165 USA Univ Edinburgh, Sch Med, Ctr Inflammat Res, Edinburgh EH3 9YW, Midlothian,Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH3 9YW Midlothian,Scotland
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 3, volume: 192, anno: 2000,
pagine: 359 - 366
SICI:
0022-1007(20000807)192:3<359:AHRFCP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE PERITONEAL-MACROPHAGES; SYSTEMIC LUPUS-ERYTHEMATOSUS; LOW-DENSITY-LIPOPROTEIN; RECEPTOR FUNCTION-INVITRO; VITRONECTIN RECEPTOR; DENDRITIC CELLS; CUTTING EDGE; IN-VITRO; PHAGOCYTOSIS; RECOGNITION;
Keywords:
systemic lupus erythematosus; complement deficiency; C1q; transgenic mice; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Walport, MJ Hammersmith Hosp, Imperial Coll, Sch Med, Div Med,Rheumatol Sect, Hammersmith Campus,Du Cane Rd, London W12 0NN, England Hammersmith HospHammersmith Campus,Du Cane Rd London England W12 0NN
Citazione:
P.R. Taylor et al., "A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo", J EXP MED, 192(3), 2000, pp. 359-366

Abstract

The strongest susceptibility genes for the development of systemic lupus erythematosus (SLE) in humans are null mutants of classical pathway complement proteins. There is a hierarchy of disease susceptibility and severity according to the position of the missing protein in the activation pathway, with the severest disease associated with C1q deficiency. Here we demonstrate, using novel in vivo models of apoptotic cell clearance during sterile peritonitis, a similar hierarchical role for classical pathway complement proteins in vivo in the clearance of apoptotic cells by macrophages. Our results constitute the first demonstration of an impairment in the phagocytosis of apoptotic cells by macrophages in vivo in a mammalian system. Apoptotic cells are thought to be a major source of the autoantigens of SLE, and impairment of their removal by complement may explain the link between hereditary complement deficiency and the development of SLE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:42:03