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Titolo:
Chronic melanocortin 4 receptor blockage causes obesity without influencing sexual behavior in male rats
Autore:
Vergoni, AV; Bertolini, A; Guidetti, G; Karefilakis, V; Filaferro, M; Wikberg, JES; Schioth, HB;
Indirizzi:
Univ Uppsala, Ctr Biomed, Dept Neurosci, S-75124 Uppsala, Sweden Univ Uppsala Uppsala Sweden S-75124 pt Neurosci, S-75124 Uppsala, Sweden Univ Modena, Dept Biomed Sci, Pharmacol Sect, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 , Pharmacol Sect, I-41100 Modena, Italy Uppsala Univ, Dept Pharmaceut Pharmacol, Uppsala, Sweden Uppsala Univ Uppsala Sweden Dept Pharmaceut Pharmacol, Uppsala, Sweden Melacure Therapeut AB, Uppsala, Sweden Melacure Therapeut AB Uppsala Sweden cure Therapeut AB, Uppsala, Sweden
Titolo Testata:
JOURNAL OF ENDOCRINOLOGY
fascicolo: 2, volume: 166, anno: 2000,
pagine: 419 - 426
SICI:
0022-0795(200008)166:2<419:CM4RBC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-MSH; SELECTIVE ANTAGONIST; FOOD-INTAKE; HS014;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Vergoni, AV Univ Uppsala, Ctr Biomed, Dept Neurosci, Box 593, S-75124 Uppsala, Sweden Univ Uppsala Box 593 Uppsala Sweden S-75124 4 Uppsala, Sweden
Citazione:
A.V. Vergoni et al., "Chronic melanocortin 4 receptor blockage causes obesity without influencing sexual behavior in male rats", J ENDOCR, 166(2), 2000, pp. 419-426

Abstract

We investigated the effects of continuous intracerebro-ventricular infusion of a melanocortin 4 receptor antagonist HS014 (cyclic [AcCys(11), D-Nal(14), Cys(18), Asp-NH222]beta-MSH-(11-22)) over 12 days and a subsequent 12-day recovery period on food intake, body weight and copulatory behavior in male rats. The results show that the food intake increased immediately afterthe start of the infusion of HS014 (0.16 nmol/h) and progressively increased thereafter. No tachyphylaxis was observed. When the infusion of HS014 was terminated, the food-intake levels dropped, The body wrights of the rats had increased by 17% by the did of the study, compared with controls. During the recovery period, the body weight decreased towards thew levels of thecontrol rats. These results indicate that overeating and the subsequent increases in body weight caused by blockage of the melanocortin 4 (MC4) receptor are reversible when the blockage is ended. We also tested the copulatory behavior of vigorous male rats in the presence of female rats in estrous. We registered mount latency, the number of mounts, the intromission latency, the number of intromissions, the ejaculation latency and the post-ejaculatory interval three times during the study and also after acute administration of HS014 and alpha-MSH. The sexual behavior of the male rats was not affected. These results indicate that the MC receptors, in particular the MC4 receptor, may not be a major mediator of effects on copulatory behavior in male rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 05:42:41