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Titolo:
Interaction between substance P and TRH in the control of prolactin release
Autore:
Duvilanski, BH; Pisera, D; Seilicovich, A; Diaz, MD; Lasaga, M; Isovich, E; Verlardez, MO;
Indirizzi:
Univ Buenos Aires, Fac Med, Ctr Invest Reprod, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1121 Aires, DF, Argentina
Titolo Testata:
JOURNAL OF ENDOCRINOLOGY
fascicolo: 2, volume: 166, anno: 2000,
pagine: 373 - 380
SICI:
0022-0795(200008)166:2<373:IBSPAT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT ANTERIOR-PITUITARY; VASOACTIVE-INTESTINAL-PEPTIDE; MESSENGER RIBONUCLEIC-ACIDS; THYROID-HORMONE STATUS; CELL IMMUNOBLOT ASSAY; GABAERGIC SYSTEM; RECEPTOR INTERNALIZATION; GENE-EXPRESSION; NEUROPEPTIDE-Y; GROWTH-HORMONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Duvilanski, BH Univ Buenos Aires, Fac Med, Ctr Invest Reprod, Piso 10,Paraguay 2155, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Piso 10,Paraguay 2155 Buenos Aires DF Argentina RA-1121
Citazione:
B.H. Duvilanski et al., "Interaction between substance P and TRH in the control of prolactin release", J ENDOCR, 166(2), 2000, pp. 373-380

Abstract

Substance P (SP) may participate as a paracrine and/or autocrine factor ill the regulation of anterior pituitary function. This project studied the effect of TRH on SP content and release from anterior pituitary and the roleof SP in TRH-induced prolactin release. TRH (10(-7) M), but not vasoactiveintestinal polypeptide (VIP), increased immunoreactive-SP (ir-SP) content and release from male rat anterior pituitary in vitro. An anti-prolactin serum also increased ir-SP release and content. In order to determine whetherintrapituitary SP participates in TRH-induced prolactin release, anterior pituitaries were incubated with TRW (10(-7) M) and either WIN 62,577, a specific antagonist of the NK1 receptor, or a specific anti-SP serum. Both WIN62,577 (10(-8) and 10(-7) M) and the anti-SP serum (1:250) blocked TRH-induced prolactin release. In order to study the interaction between TRH and SP on prolactin release, anterior pituitaries were incubated with either TRH(10(-7) M) or SP, or with both peptides. SP (10(-7) and 10(-6) M) by itself stimulated prolactin release. While 10(-7) M SP did not modify the TRH effect, 10(-6) M SP reduced TRH-stimulated prolactin release. SP (10(-5) M) alone failed to stimulate prolactin release and markedly decreased TRH-induced prolactin release. The present study shows that TRH stimulates ir-SP release and increases ir-SP content in the anterior pituitary. Our data also suggest that SP may act as a modulator of TRH effect on prolactin secretion by a paracrine mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 00:02:33