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Titolo:
Evaluation of lung cancer by Tc-99m-tetrofosmin SPECT: Comparison with [F-18]FDG-PET
Autore:
Tatsumi, M; Yutani, K; Nishimura, T;
Indirizzi:
Osaka Univ, Grad Sch Med, Ctr Biomed Res, Div Tracer Kinet, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 r Kinet, Suita, Osaka 5650871, Japan
Titolo Testata:
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
fascicolo: 4, volume: 24, anno: 2000,
pagine: 574 - 580
SICI:
0363-8715(200007/08)24:4<574:EOLCBT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOTON-EMISSION TOMOGRAPHY; TC-99M TETROFOSMIN; FDG-PET; BREAST-CANCER; GLUCOSE-TRANSPORT; TL-201 SPECT; CELL-LINES; F-18 FDG; TECHNETIUM-99M-TETROFOSMIN; LESIONS;
Keywords:
Tc-99m-tetrofosmin; emission computed tomography; lungs, cancer; lungs; [F-18]fluorodeoxyglucose;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Nishimura, T Osaka Univ, Grad Sch Med, Ctr Biomed Res, Div Tracer Kinet, D9,2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ D9,2-2 Yamadaoka Suita Osaka Japan 5650871 , Japan
Citazione:
M. Tatsumi et al., "Evaluation of lung cancer by Tc-99m-tetrofosmin SPECT: Comparison with [F-18]FDG-PET", J COMPUT AS, 24(4), 2000, pp. 574-580

Abstract

Purpose: The purpose of this study was to clarify the validity of Tc-99m-tetrofosmin SPECT (TF-SPECT) in the evaluation of lung cancer in comparison with [F-18]fluorodeoxyglucose ([F-18]FDG-PET). Method: Twenty-one patients with biopsy-proven non-small cell lung cancer were examined by both TF-SPECT (early and delayed images) and FDG-PET within a week of each study. Lung cancers were analyzed visually and semiquantitatively using the ratio of lesion to background counts (L/B ratio). Mediastinal lymph node metastases were analyzed only visually. Results: Both early and delayed TF images could detect 18 of 21 lung cancers on visual analysis (85.7%), whereas FDG-PET could detect all the lesions(100%). The WE ratio of TF-SPECT was significantly higher in delayed than in early images (1.79 +/- 0.55 vs. 1.56 +/- 0.40; p < 0.001). However, the WE ratio of FDG-PET was 8.85 +/- 3.05, significantly higher than those of both TF images (p < 0.0001). In the assessment of mediastinal involvement, TF-SPECT was 40.0% sensitive, 100% specific, and 71.4% accurate, whereas FDG-PET was 80.0% sensitive, 81.8% specific, and 81.0% accurate. Conclusion: Although the detection sensitivity was far better than expected, TF-SPECT is not considered to be an alternative to FDG-PET in the evaluation of malignant pulmonary lesions because of its significantly low LIE ratio. TF-SPECT has poor sensitivity for mediastinal lymph node metastases and is useless for staging patients with lung cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:55:46