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Titolo:
Milrinone, not epinephrine, improves left ventricular compliance after cardiopulmonary bypass
Autore:
Lobato, EB; Gravenstein, N; Martin, TD;
Indirizzi:
Univ Florida, Coll Med, Dept Anesthesiol, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 sthesiol, Gainesville, FL 32610 USA Univ Florida, Coll Med, Dept Neurosurg, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 eurosurg, Gainesville, FL 32610 USA Univ Florida, Coll Med, Dept Cardiovasc Surg, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 asc Surg, Gainesville, FL 32610 USA
Titolo Testata:
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
fascicolo: 4, volume: 14, anno: 2000,
pagine: 374 - 377
SICI:
1053-0770(200008)14:4<374:MNEILV>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE HEART-FAILURE; INTRAVENOUS MILRINONE; MYOCARDIAL ENERGETICS; DIASTOLIC FUNCTION; ISCHEMIC ARREST; CARDIOPLEGIA; DOBUTAMINE; SURGERY; REVASCULARIZATION; HEMODYNAMICS;
Keywords:
milrinone; epinephrine; cardiopulmonary bypass; left ventricular compliance; aortocoronary bypass;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Lobato, EB Univ Florida, Coll Med, Dept Anesthesiol, Box 100254 JHMHSC, Gainesville, FL 32610 USA Univ Florida Box 100254 JHMHSC Gainesville FL USA 32610 610 USA
Citazione:
E.B. Lobato et al., "Milrinone, not epinephrine, improves left ventricular compliance after cardiopulmonary bypass", J CARDIOTHO, 14(4), 2000, pp. 374-377

Abstract

Objective: To compare the effects of milrinone versus epinephrine administered after cardiopulmonary bypass (CPB) on left ventricular compliance,Design: Prospective and randomized. Setting: University-affiliate hospital. Participants: Twenty consenting adult patients. Interventions: Patients undergoing aortocoronary bypass surgery were randomized to receive 50 mu g/kg of milrinone [group M; n = 10) or 0.03 mu g/kg/min of epinephrine (group E; n = 10) shortly after separation from CPB, Left ventricular compliance was assessed by observing changes in left ventricular end-diastolic area (LVEDA) in the short-axis view with transesophageal echocardiography, while maintaining a constant left atrial pressure. Measurements were performed (1) before CPB, (2) after separation from CPB, and (3) after either milrinone or epinephrine. Measurements and Main Results: Baseline LVEDA decreased by 20% after CPB in the milrinone group (from 16.6 +/- 3.1 cm(2) to 14.3 +/- 2.4 cm(2); p < 0.05) and by 22% in the epinephrine group (from 19.4 +/- 4.1 cm(2) to 17.2 +/- 3.8 cm(2); p < 0.05), LVEDA increased by 15% after milrinone (from 14.3 /- 2.4 cm(2) to 15.6 +/- 2.8 cm(2); p < 0.05) but remained unchanged afterepinephrine (from 17.2+/-3.8 cm(2) to 17.1 +/- 4.2 cm(2); p = ns),Conclusions: Left ventricular compliance was decreased after CPB, The administration of milrinone, but not epinephrine, was associated with a partialreturn to prebypass values. The exact mechanism of action remains to be determined. Copyright (C) 2000 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:58:02