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Titolo:
Porphyromonas gingivalis proteinases as virulence determinants in progression of periodontal diseases
Autore:
Kadowaki, T; Nakayama, K; Okamoto, K; Abe, N; Baba, A; Shi, YX; Ratnayake, DB; Yamamoto, K;
Indirizzi:
Kyushu Univ, Fac Dent, Dept Pharmacol, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ol, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ, Fac Dent, Dept Microbiol, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ol, Higashi Ku, Fukuoka 8128582, Japan
Titolo Testata:
JOURNAL OF BIOCHEMISTRY
fascicolo: 2, volume: 128, anno: 2000,
pagine: 153 - 159
SICI:
0021-924X(200008)128:2<153:PGPAVD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANAEROBE BACTEROIDES-GINGIVALIS; ARGININE-SPECIFIC PROTEINASES; TRYPSIN-LIKE PROTEASE; CYSTEINE PROTEINASE; ARG-GINGIPAIN; STRUCTURAL CHARACTERIZATION; COLLAGENOLYTIC ACTIVITY; MOLECULAR-CLONING; EPITHELIAL-CELLS; ENCODING GENES;
Keywords:
Arg-gingipain; cysteine proteinases; Lys-gingipain; periodontal diseases; Porphyromonas gingivalis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamoto, K Kyushu Univ, Fac Dent, Dept Pharmacol, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 Ku, Fukuoka 8128582, Japan
Citazione:
T. Kadowaki et al., "Porphyromonas gingivalis proteinases as virulence determinants in progression of periodontal diseases", J BIOCHEM, 128(2), 2000, pp. 153-159

Abstract

Porphyromonas gingivalis, one of the major causative agents of periodontaldiseases, produces large amounts of arginine- and lysine-specific cysteineproteinases in cell-associated and secretory forms, which are now referredto as Arg-gingipain (Ptgp) and Lys-gingipain (Kgp), respectively. A numberof studies have revealed that these proteinases are closely associated with the periodontopathogenesis of this bacterium: destruction of periodontal connective tissues, disruption of host defense mechanisms, and development and maintenance of inflammation in periodontal pockets. With respect to thephysiology of the bacterium, Rgp and Kgp are indispensable for it to obtain nutrients from the environment, since it cannot utilize saccharides as carbon/energy sources for growth and totally depends on peptides and amino acids that are provided from environmental proteins by Rgp and Kgp. Furthermore, proteolytic activities of Rgp and Kgp contribute to processing/maturation of various cell-surface proteins of P. gingivalis, such as fimA fimbrilin (a subunit of major fimbriae), 75-kDa protein (a subunit of minor fimbriae), hemagglutinins, and the hemoglobin receptor protein, which are important for the bacterium to colonize and proliferate in the gingival crevice andto invade the periodontium. These findings strongly indicate critical roles of Rgp and Kgp in the virulence of P. gingivalis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:47:56