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Titolo:
HISTOCHEMICAL EVALUATION OF PLACENTAL DIPEPTIDYL PEPTIDASE-IV (CD26) IN PREECLAMPSIA - ENZYME-ACTIVITY IN VILLOUS TROPHOBLAST INDICATES AN ENHANCED LIKELIHOOD OF GESTATIONAL HYPERTENSIVE DISORDERS
Autore:
NEUDECK H; JONCIC M; SCHUSTER C; BISSON S; HILDEBRANDT R; ONEY T; STIEMER B; HOPP H; GRAF R;
Indirizzi:
FREE UNIV BERLIN,UNIV KLINIKUM BENJAMIN FRANKLIN,INST ANAT,KONIGIN LUISE STR 15 D-14195 BERLIN GERMANY FREE UNIV BERLIN,UNIV KLINIKUM BENJAMIN FRANKLIN,INST TOXICOL & EMBRYOPHARMACOL D-14195 BERLIN GERMANY FREE UNIV BERLIN,UNIV KLINIKUM BENJAMIN FRANKLIN,INST MED STAT D-14195 BERLIN GERMANY FREE UNIV BERLIN,UNIV KLINIKUM BENJAMIN FRANKLIN,FRAUENKLIN & POLIKLIN D-14195 BERLIN GERMANY
Titolo Testata:
American journal of reproductive immunology [1989]
fascicolo: 6, volume: 37, anno: 1997,
pagine: 449 - 458
SICI:
1046-7408(1997)37:6<449:HEOPDP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANCE-P; AMINOPEPTIDASE-M; DIPEPTIDYL(AMINO)PEPTIDASE-IV; PROLIFERATION; CANCER; INVIVO;
Keywords:
CD26; DIPEPTIDYL PEPTIDASE IV; DPP IV; HUMAN PLACENTA; PREECLAMPSIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
H. Neudeck et al., "HISTOCHEMICAL EVALUATION OF PLACENTAL DIPEPTIDYL PEPTIDASE-IV (CD26) IN PREECLAMPSIA - ENZYME-ACTIVITY IN VILLOUS TROPHOBLAST INDICATES AN ENHANCED LIKELIHOOD OF GESTATIONAL HYPERTENSIVE DISORDERS", American journal of reproductive immunology [1989], 37(6), 1997, pp. 449-458

Abstract

PROBLEM: To determine whether differences in placental dipeptidyl peptidase IV (DPP IV, CD26) activities occurred in hypertensive complicated pregnancies as compared with uncomplicated pregnancies. METHOD: DPPIV activity was detected with H-Gly-Pro-4M2NA as the substrate in placental cryostat sections from 65 patients with gestational hypertension and 67 patients with uncomplicated pregnancies. The graduated intensities of the reaction product in the villous trophoblast were scored semiquantitatively by light microscopy and were related to the relativefrequencies of hypertensive disorders (proportional odds model). After detection of enzyme activity, the same tissue samples were homogenized and used for kinetic fluorometric measurements. RESULTS: Enhanced villous trophoblastic DPP IV activity was significantly associated withan increased frequency of proteinuric hypertension in pregnant women (cumulative odds ratio <(theta)over cap>(1) = 1.6; P < 0.01). CONCLUSION: This study demonstrates for the first time that increased villous trophoblastic DPP IV activity indicates an increased likelihood of thepresence and of the severity of hypertensive disorders in pregnancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:47:12