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Titolo:
Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation
Autore:
Kuniyasu, Y; Takahashi, T; Itoh, M; Shimizu, J; Toda, G; Sakaguchi, S;
Indirizzi:
Tokyo Metropolitan Inst Gerontol, Dept Immunopathol, Tokyo 1730015, Japan Tokyo Metropolitan Inst Gerontol Tokyo Japan 1730015 okyo 1730015, Japan Jikei Med Univ, Dept Med, Tokyo 3050006, Japan Jikei Med Univ Tokyo Japan 3050006 Univ, Dept Med, Tokyo 3050006, Japan Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 i, Dept Expt Pathol, Kyoto 6068507, Japan
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 8, volume: 12, anno: 2000,
pagine: 1145 - 1155
SICI:
0953-8178(200008)12:8<1145:NAASCT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOLOGICAL SELF-TOLERANCE; AUTOIMMUNE-DISEASE; IN-VITRO; MONOCLONAL-ANTIBODY; LYMPHOCYTES-T; ADOPTIVE TRANSFER; IL-2 RECEPTOR; INDUCTION; MICE; ANTIGEN;
Keywords:
anergy; autoimmune disease; immunoregulation; self-tolerance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Sakaguchi, S Tokyo Metropolitan Inst Gerontol, Dept Immunopathol, Tokyo 1730015, Japan Tokyo Metropolitan Inst Gerontol Tokyo Japan 1730015 Japan
Citazione:
Y. Kuniyasu et al., "Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation", INT IMMUNOL, 12(8), 2000, pp. 1145-1155

Abstract

A CD4(+) T cell subpopulation defined by the expression levels of a particular cell surface molecule (e.g. CD5, CD45RB, CD25, CD62L or CD38) bears anautoimmune-preventive activity in various animal models. Here we show thatthe expression of CD25 is highly specific, when compared with other molecules, in delineating the autoimmune-preventive immunoregulatory CD4(+) T cell population. Furthermore, although CD25 is an activation marker for T cells, the following findings indicate that immunoregulatory CD25(+)CD4(+) T cells are functionally distinct from activated or anergy-induced T cells derived from CD25(-)CD4(+) T cells. First, the former are autoimmune-preventivein vivo, naturally unresponsive (anergic) to TCR stimulation in vitro and,upon TCR stimulation, able to suppress the activation/proliferation of other T cells, whereas the latter scarcely exhibit the in vivo autoimmune-preventive activity or the in vitro suppressive activity. Second, such activated or anergy-induced CD25- spleen cells produce various autoimmune diseases when transferred to syngeneic athymic nude mice, whereas similarly treated normal spleen cells, which include CD25(+)CD4(+) T cells, do not. Third, upon polyclonal T cell stimulation, CD25(+)CD(4+) T cells express CD25 at higher levels and more persistently than CD25(+)CD4(+) T cell-derived activated T cells; moreover, when the stimulation is ceased, the former revert to the original levels of CD25 expression, whereas the latter lose the expression. These results collectively indicate that naturally anergic and suppressive CD25(+)CD4(+) T cells present in normal naive mice are functionally andphenotypically stable, distinct from other T cells, and play a key role inmaintaining immunologic self-tolerance.

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Documento generato il 02/04/20 alle ore 02:46:26