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Titolo:
Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine
Autore:
Kim, HM; An, NH; Yi, BH; Chae, HJ; Kim, HR; Moon, SJ; Kim, JJ; Park, ST; Baek, SH;
Indirizzi:
Wonkwang Univ, Sch Med, Coll Pharm, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Sch Dent, Dept Dent Pharmacol, Iksan 570749, Chonbuk, SouthKorea Wonkwang Univ Iksan Chonbuk South Korea 570749 70749, Chonbuk, SouthKorea Wonkwang Univ, Sch Med, Coll Oriental Med, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Sch Med, Dept Anat, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Ctr Oriental Med Sci, Profess Grad Sch Oriental Med, Dept Nat Prod, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea
Titolo Testata:
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
fascicolo: 2, volume: 22, anno: 2000,
pagine: 253 - 266
SICI:
0892-3973(2000)22:2<253:IEOMCI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTAMINE-RELEASE; SUBSTANCE-P; SKIN; ACTIVATION; MECHANISM; PROTEINS; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, HM Wonkwang Univ, Sch Med, Coll Pharm, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 onbuk, South Korea
Citazione:
H.M. Kim et al., "Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine", IMMUNOPH IM, 22(2), 2000, pp. 253-266

Abstract

We examined the effect of sulfapyridine on mast cell-mediated immediate-type allergic reactions. Sulfapyridine (1 and 10 mu g/kg) significantly inhibited systemic allergic reaction induced by compound 48/80 in rats. Sulfapyridine (1 and 10 mu g/kg) also inhibited significantly local mast cell-mediated immediate-type allergic reactions activated by anti-dinitrophenyl (DNP)IgE. Moreover, sulfapyridine inhibited histamine release dose-dependently in the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. When sulfapyridine was added, the level of cAMP in RPMC, transiently and significantly increased about 4-fold compared with that of basal cells. These results indicate that sulfapyridine inhibits mast cell-mediated immediate-type allergic reactions in vivo and in vitro.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:13:29