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Titolo:
Progressive reduction of CMV-specific CD4(+) T cells in HIV-1 infected individuals during antiretroviral therapy
Autore:
Grosse, V; Schulte, A; Weber, K; Mendila, M; Jacobs, R; Schmidt, RE; Heiken, H;
Indirizzi:
Med Hsch Hannover, Abt Klin Immunol, D-30625 Hannover, Germany Med Hsch Hannover Hannover Germany D-30625 ol, D-30625 Hannover, Germany
Titolo Testata:
IMMUNOBIOLOGY
fascicolo: 2, volume: 202, anno: 2000,
pagine: 179 - 185
SICI:
0171-2985(200008)202:2<179:PROCCT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CYTOMEGALOVIRUS RETINITIS; FLOW-CYTOMETRY; BONE-MARROW; AIDS; DISEASE; VIREMIA; REPERTOIRE; DECLINE; CLONES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Heiken, H Med Hsch Hannover, Abt Klin Immunol, Carl Neuberg Str 1, D-30625Hannover,Germany Med Hsch Hannover Carl Neuberg Str 1 Hannover Germany D-30625 y
Citazione:
V. Grosse et al., "Progressive reduction of CMV-specific CD4(+) T cells in HIV-1 infected individuals during antiretroviral therapy", IMMUNOBIOL, 202(2), 2000, pp. 179-185

Abstract

Visualization of antigen-specific T cells has become an important tool in studying immune responses. The aim of this study was to analyze CMV-specific CD4(+) T cells in healthy and HIV-infected individuals. Peripheral blood mononuclear cells (PBMC) were examined for antigen-induced intracellular cytokine responses. We found significant numbers of CMV-specific CD4(+) T cells detectable in most CMV-IgG* HIV-1 infected individuals, whereas CMV-specific CD4(+) T cells could not be demonstrated in CMV-IgG(-) patients. Median frequency of CMV-specific CD4(+) T cells were lower in HIV-infected subjects who had been treated with highly active antiretroviral therapy (HAART) for more than 1 year than in untreated HIV-infected individuals. In patients under therapy for less than 1 year median CMV-specific CD4(+) T cell responder frequency was higher than in subjects treated for more than 1 year but lower than in untreated subjects. HIV suppression with HAART might lead to a progressive reduction of CMV-specific CD4(+) T cells indicating an efficient elimination of an opportunistic pathogen.

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Documento generato il 22/09/20 alle ore 23:46:35